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. 2019 Apr 3;13:126. doi: 10.3389/fncel.2019.00126

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Copyright © 2019 Arac, Grimbaldeston, Galli, Bliss and Steinberg.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Scheme shows how the brain is enveloped by the meninges that contain Mast cells (MCs) in both the dura mater and pia mater. (B) Before entering the brain parenchyma, blood vessels course on the surface of the brain between the dura mater and pia mater. Therefore, as a resident immune cell in the meninges, the MC has the potential to influence blood vessels and to function as a gatekeeper to influence brain inflammation and pathology. Reprinted from Arac et al. (2014) with permission from Elsevier.