Table 2.
Potential pleiotropic SNPs and their associated disease groups
| SNP | Circulatory NeglogP(Uni-variate) | Nervous NeglogP(Uni-variate) | NeglogP (Bi- variate) |
NeglogP (Multi variate) |
Tissue count |
eGenes |
|---|---|---|---|---|---|---|
| 1:36822024 rs10796883 |
Cardiac_dysrhythmias(11.305) | Muscular dystrophies and other myopathies(4.921) | 13.247 | 11.165 | 35 | EVA1B, TRAPPC3 |
| Other conditions of brain(3.451) | 12.030 | 35 | EVA1B, TRAPPC3 | |||
| Pain(4.151) | 12.363 | 35 | EVA1B, TRAPPC3 | |||
| Essential hypertension(9.125) | Muscular dystrophies and other myopathies(4.921) | 11.325 | 35 | EVA1B, TRAPPC3 | ||
| Heart_failure(10.029) | Muscular dystrophies and other myopathies(4.921) | 11.988 | 35 | EVA1B, TRAPPC3 | ||
| Pain(4.151) | 11.452 | 35 | EVA1B, TRAPPC3 | |||
| Hypotension(8.660) | Muscular dystrophies and other myopathies(4.921) | 10.699 | 35 | EVA1B, TRAPPC3 | ||
| 6:32569056 rs9270779 |
Atherosclerosis(14.165) | Multiple sclerosis(6.355) | 18.112 | 10.861 | 8 | HLA-DRB5, HLA-DRB9 |
| Parkinson’s disease(3.196) | 15.097 | 11 | HLA-DRB5, HLA-DRB9 | |||
| Occlusion_and_stenosis_of_precerebral_arter ies(6.355) |
Multiple sclerosis(5.913) | 10.400 | 7 | HLA-DRB5, HLA-DRB9 | ||
| Other peripheral vascular disease(6.355) | Multiple sclerosis(7.442) | 11.787 | 4 | HLA-DRB5, HLA-DRB9 | ||
| 14:106995720 rs716 0440 | Cardiac_dysrhythmias(11.322) | Muscular dystrophies and other myopathies(4.394) | 12.989 | 18.291 | 5 | IGHV3–53,IGHV4–39, IGHV3–49 |
| Other conditions of brain(3.726) | 12.420 | 5 | IGHV3–53,IGHV4–39, IGHV3–49 | |||
| Pain(6.297) | 14.259 | 5 | IGHV3–53,IGHV4–39, IGHV3–49 | |||
| Essential hypertension(7.451) | Pain(6.297) | 10.610 | 1 | IGHV3–49 | ||
| Heart_failure(9.038) | Muscular dystrophies and other myopathies(4.394) | 10.752 | 8 | IGHV3–53,IGHV4–39, IGHV3–49, HOMER2P1 | ||
| Other conditions of brain(3.726) | 10.469 | 6 | IGHV3–53,IGHV4–39, IGHV3–49 | |||
| Pain(6.297) | 12.465 | 5 | IGHV3–53,IGHV4–39, IGHV3–49 | |||
| Hypertensive chronic kidney disease(8.116) | Pain(6.297) | 11.623 | 5 | IGHV3–53,IGHV4–39, IGHV3–49 | ||
| Hypotension(10.278) | Muscular dystrophies and other myopathies(4.394) | 11.832 | 5 | IGHV3–53,IGHV4–39, IGHV3–49 | ||
| Other conditions of brain(3.726) | 11.252 | 5 | IGHV3–53,IGHV4–39, IGHV3–49 | |||
| Pain(6.297) | 13.004 | 5 | IGHV3–53,IGHV4–39, IGHV3–49 | |||
| Ill- defined_descriptions_and_complications_of_ heart disease(7.610) |
Pain(6.297) | 11.224 | 1 | |||
| 22:22876236 rs361535 |
Other_forms_of_chronic_ischemic_heart_dis ease(4.985) |
Inflammatory and toxic neuropathy(14.211) | 14.702 | 10.424 | 1 | |
| 22:22947156 rs2097594 |
Cardiac_dysrhythmias(10.930) | Inflammatory and toxic neuropathy(3.011) | 11.236 | 28.019 | 1 | |
| Muscular dystrophies and other myopathies(3.773) | 12.116 | 1 | ||||
| Other conditions of brain(3.328) | 11.738 | 1 | ||||
| Pain(5.622) | 13.348 | 1 | ||||
| Cardiomyopathy(12.330) | Inflammatory and toxic neuropathy(3.011) | 12.818 | 2 | GGTLC2 | ||
| Muscular dystrophies and other myopathies(3.773) | 13.768 | 2 | IGLV3–21, GGTLC2 | |||
| Other conditions of brain(3.328) | 13.507 | 1 | GGTLC2 | |||
| Pain(5.622) | 15.503 | 2 | GGTLC2 | |||
| Essential_hypertension(10.187) | Muscular dystrophies and other myopathies(3.773) | 11.380 | 2 | BCRP4 | ||
| Other conditions of brain(3.328) | 10.968 | |||||
| Pain(5.622) | 12.386 | |||||
| Heart_failure(20.621) | Inflammatory and toxic neuropathy(3.011) | 19.807 | 2 | GGTLC2 | ||
| Muscular dystrophies and other myopathies(3.773) | 20.963 | 3 | IGLV3–21, GGTLC2 | |||
| Other conditions of brain(3.328) | 21.000 | 2 | GGTLC2 | |||
| Pain(5.622) | 22.553 | 2 | GGTLC2 | |||
| Hypertensive_chronic_kidney_disease(9.331) | Muscular dystrophies and other myopathies(3.773) | 10.760 | 2 | GGTLC2 | ||
| Pain(5.622) | 12.119 | 2 | GGTLC2 | |||
| Hypotension(9.778) | Muscular dystrophies and other myopathies(3.773) | 10.883 | 2 | GGTLC2 | ||
| Other conditions of brain(3.328) | 10.491 | 2 | GGTLC2 | |||
| Pain(5.622) | 12.026 | 2 | GGTLC2 | |||
| Ill- defined_descriptions_and_complications_of_ heart_disease(10.665) |
Inflammatory and toxic neuropathy(3.011) | 10.863 | 2 | GGTLC2 | ||
| Muscular dystrophies and other myopathies(3.773) | 11.703 | 2 | GGTLC2 | |||
| Other conditions of brain(3.328) | 11.478 | 2 | GGTLC2 | |||
| Pain(5.622) | 13.385 | 2 | GGTLC2 | |||
| Other_diseases_of_endocardium(10.340) | Inflammatory and toxic neuropathy(10.340) | 11.032 | ||||
| Muscular dystrophies and other myopathies(10.340) | 11.844 | |||||
| Other conditions of brain(10.340) | 11.617 | |||||
| Pain(5.622) | 13.627 | |||||
| Other forms of chronic ischemic heart dis ease(11.873) | Inflammatory and toxic neuropathy(11.873) | 11.335 | ||||
| Muscular dystrophies and other myopathies(11.873) | 12.690 | |||||
| Other conditions of brain(11.873) | 12.530 | |||||
| Pain(5.622) | 14.168 | |||||
| 22:25420792 rs13056641 |
Cardiac_dysrhythmias(9.528) | Inflammatory and toxic neuropathy(4.159) | 10.817 | 40.505 | 11 | KIAA1671, SGSM1, CRYBB2, CRYBB3, IGLL3P |
| Organic sleep disorders(4.166) | 10.687 | 1 | IGLL3P | |||
| Pain(4.590) | 11.247 | 6 | KIAA1671, IGLL3P | |||
| Essential_hypertension(12.162) | Inflammatory and toxic neuropathy(4.159) | 12.620 | 16 | KIAA1671, SGSM1, CRYBB2, CRYBB3, IGLL3P, BCRP3 | ||
| Organic sleep disorders(4.166) | 12.521 | 1 | IGLL3P | |||
| Pain(4.590) | 13.284 | 7 | KIAA1671, IGLL3P | |||
| 22:25436904 rs1040421 |
Angina pectoris(3.067) | Pain(13.338) | 15.015 | 58.239 | 7 | KIAA1671, SGSM1, IGLL3P |
| Atherosclerosis(5.075) | Pain(13.338) | 15.580 | 8 | KIAA1671, SGSM1, IGLL3P | ||
| Cardiac dysrhythmias(11.931) | Pain(13.338) | 20.872 | 7 | KIAA1671, SGSM1, IGLL3P | ||
| Cardiomyopathy(4.939) | Pain(13.338) | 15.904 | 8 | KIAA1671, SGSM1, IGLL3P | ||
| Conduction disorders(5.764) | Pain(13.338) | 16.372 | 5 | KIAA1671, SGSM1, IGLL3P | ||
| Essential_hypertension(10.303) | Pain(13.338) | 19.175 | 8 | KIAA1671, SGSM1, IGLL3P | ||
| Heart failure(7.101) | Pain(13.338) | 17.129 | 8 | KIAA1671, SGSM1, IGLL3P | ||
| Hypertensive chronic kidney disease(7.426) | Pain(13.338) | 17.404 | 8 | KIAA1671, SGSM1, IGLL3P | ||
| Hypotension(6.693) | Pain(13.338) | 16.037 | 4 | KIAA1671, SGSM1, IGLL3P | ||
| Other diseases of endocardium(5.845) | Pain(13.338) | 16.677 | 4 | KIAA1671, SGSM1, IGLL3P | ||
| 22:28250172 rs1997739 |
Cardiac_dysrhythmias(10.517) | Pain(4.966) | 12.443 | 22.064 | 19 | ZNRF3, TTC28-AS1 |
| 22:33079917 rs5749490 |
Cardiac_dysrhythmias(11.280) | Hereditary and idiopathic peripheral neuropathy(3.04 9) |
11.884 | 23.601 | 9 | FBXO7, SLC5A4-AS1 |
| Inflammatory and toxic neuropathy(3.958) | 12.254 | 2 | FBXO7, SLC5A4-AS1 | |||
| Mononeuritis of lower limb and unspecified site(3.1 53) | 12.242 | 2 | FBXO7, SLC5A4-AS1 | |||
| Pain(8.424) | 16.011 | 9 | FBXO7, SLC5A4-AS1 | |||
| Hypertensive chronic kidney disease(6.449) | Pain(8.424) | 12.064 | 9 | FBXO7, SLC5A4-AS1 | ||
| Hypertensive heart disease(4.191) | Pain(8.424) | 10.592 | 10 | FBXO7, SLC5A4-AS1 | ||
| Hypotension(8.197) | Pain(8.424) | 12.959 | 3 | FBXO7, SLC5A4-AS1 |
Notes: We left as missing in the table any eGene (Ensembl gene ID from GTEx) that did not have an HGNC symbol counterpart.