Skip to main content
. Author manuscript; available in PMC: 2019 Apr 10.
Published in final edited form as: ACS Appl Mater Interfaces. 2016 Nov 7;8(45):30735–30746. doi: 10.1021/acsami.6b10306

Figure 7.

Figure 7.

HNPs maintains its gene delivery capability in mouse mammary xenograft tumor tissues while PEG-NP and PEI25k lost that. The mouse mammary tumors were produced as described in the Experimental Section. A single dose of HNPs loaded with 25 μg of Luc2 expressing pDNA was introduced into tumor tissues through an intratumoral injection. Twenty-four and forty-eight hours later, the animal was given D-luciferin by intraperitoneal injection, and the activity of tumor tissue-expressed Luc2 was determined by measuring the intensity of chemiluminescence signals using an IVIS live animal bioluminescence imaging system as described in the Experimental Section. The photo is a representative image showing strong chemiluminescence signals in mouse mammary tumor tissue (n = 3).