Table 4. This table shows the effect of adding the median of total brachial artery reactivity to a model with Framingham risk factors and the full participant population shown in Tables 1 and 3.
| Variable | Hazard Ratio | Lower 95% CI | Upper 95% CI | p-value |
|---|---|---|---|---|
| Age (years) | 1.06 | 1.05 | 1.08 | < 0.001 |
| Sex (male) | 1.65 | 1.28 | 2.13 | < 0.001 |
| Current Smoker (yes) | 1.73 | 1.27 | 2.36 | 0.001 |
| Diabetes (yes) | 1.70 | 1.24 | 2.33 | 0.001 |
| Systolic Pressure (20.0 mmHg)† | 1.25 | 1.11 | 1.40 | < 0.001 |
| LDL cholesterol (31.4 mg/dL)† | 1.06 | 0.94 | 1.19 | 0.36 |
| HDL cholesterol (14.6 mg/dL)† | 0.81 | 0.70 | 0.93 | 0.002 |
| Median total brachial artery reactivity (%) | 0.69 | 0.55 | 0.87 | 0.001 |
Population size is 5483 (5499 discounting 16 events close to enrollment).
† Reported for a change of one standard deviation.
765 participants had low amplitude TBAR responses possibly due to noise or low amplitude responses; the TBAR values were assigned a value of 0.0%.
Statistical model is also adjusted for race/ethnicity.