Fig 2. Sensitivity of EN1 provirus and plasma virus clones to neutralization by autologous serum and bN-mAbs presented in the order of the phylogenetic tree.

Source/clone represents pseudoviruses prepared using cloned envelope glycoprotein genes derived from plasma virus RNA or provirus DNA (highlighted in black). For serum, neutralization titers (SNT) indicate the reciprocal of the serum dilution that results in 50% inhibition (ID50) of target cell infection. For mAbs, neutralization titers indicate the concentration (μg/mL) of bN-mAbs (IC50) that results in 50% inhibition of target cell infection. Values in bold represent significant neutralization titers that are at least three times greater than those observed against the negative control (aMLV). ND indicates assay not done. Values >10 and >25 indicate no neutralization at concentrations of bNAbs of 10μg/ml and 25 μg/ml, respectively.