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. 2019 Apr 10;14(4):e0213528. doi: 10.1371/journal.pone.0213528

Table 2. Cerebral anatomical injuries detected on morphological MRI sequences.

LIS patients/ Lesions topography 1 2 3
Pons (left or right side of the pons) Corticospinal tract, Medial lemniscus, Parietotemporopontine tract, Ventral trigeminothalamic tract, Middle cerebellar peduncle, Frontopontine tract, Gigantocellular reticular nucleus, Pontine nuclei, B6 & B8 serotonergic cell groups, Medial longitudinal fasciculus, Corticopontine tract, Nucleus of abducens nerve, Trapezoid body, Central tegmental tract Corticospinal tract, Medial lemniscus, Parietotemporopontine tract, Ventral trigeminothalamic tract, Middle cerebellar peduncle, Pontine nuclei, Trapezoid body, Spinothalamic tract, Central tegmental tract, Superior olivary complex, B6 & B8 serotonergic cell groups, Caudal pontine reticular nucleus, Gigantocellular reticular nucleus, A5, A6, A7 noradrenergic cell groups, Lateral tegmental field, Medial tegmental field, Pontine nuclei, Rubrospinal tract, Tectospinal tract, Medial longitudinal fasciculus Corticospinal tract, Medial lemniscus, Parietotemporopontine tract, Ventral trigeminothalamic tract, Dorsal trigeminothalamic tract, Central tegmental tract, Spinothalamic tract, Trapezoid body, Locus Caeruleus (A6) + subcaerulean nucleus, Dorsal catecholaminergic tract, Longitudinal dorsal fasciculus, A5 & A7 noradrenergic cell groups
Supratentorial region No injuries No injuries No injuries
LIS patients/ Lesion topography 4 5
Pons (left or right side of the pons) Corticospinal tract, Medial lemniscus, Parietotemporopontine tract, Ventral trigeminothalamic tract, Dorsal trigeminothalamic tract, Middle cerebellar peduncle, B3 & B4 serotoninergic cell groups, B6 & B7 serotoninergic cell groups, Medial longitudinal fasciculus, Nucleus of abducens nerve, Genu of facial nerve (VII), Rubrospinal tract, Central tegmental tract, Tectospinal tract, Locus Caeruleus (A6) + subcaerulean nucleus, Mesencephalic tract of trigeminal nerve Corticospinal tract, Medial lemniscus, Parietotemporopontine tract, Ventral trigeminothalamic tract, Dorsal trigeminothalamic tract, Middle cerebellar peduncle, Pontine nuclei, Trapezoid body, Spinothalamic tract, Central tegmental tract, Superior olivary complex, Nucleus of abducens nerve, Genu of facial nerve (VII), B3 & B4 serotoninergic cell groups, B6 & B7 serotoninergic cell groups, Medial longitudinal fasciculus, Locus Caeruleus (A6) + subcaerulean nucleus, Medial superior central nucleus, Lateral superior central nucleus, Mesencephalic nucleus and tract of trigeminal nerve
Supra tentorial region No injuries No injuries
LIS patients/ Lesions topography 6 7
Pons (left or right side of the pons) Medial lemniscus, Ventral trigeminothalamic tract, Dorsal trigeminothalamic tract, Locus Caeruleus (A6) + subcaerulean nucleus, Mesencephalic nucleus and tract of trigeminal nerve, Superior cerebellar peduncle, Medial longitudinal fasciculus, Central tegmental tract, Medial superior central nucleus, Lateral superior central nucleus, Spinothalamic tract, Ventral nucleus of the lateral lemniscus, Lateral lemniscus Medial lemniscus, Spinothalamic tract, A8 dopaminergic cell group
Pontine nuclei, Vestibular nucleus, Collicular nucleus, Pontine reticular nucleus, Tectospinal tract, Periaqueductal grey substance, Medial longitudinal fasciculus, Frontopontin tract
Left side of the midbrain Periaqueductal grey substance, Inferior colliculus, Spinothalamic tract, Ventral trigeminothalamic tract, Dorsal trigeminothalamic tract, Central tegmental tract, Lateral mesencéphalic nucleus, B3 & B4 serotoninergic cell groups, B6 & B7 serotoninergic cell groups, A8 noradrenergic cell groups, Tegmental olivary tract, Medial lemniscus, Superior colliculus, Medial geniculate body No injuries
Supratentorial region Posterior hypothalamic nucleus
Habenular nuclei
No injuries