Table 3. Univariate analysis of survival and major neonatal morbidities1 between premedicated and non-premedicated neonates.
| Outcomes at hospital discharge a | Premedication (n = 76) | No premedication (n = 1418) | P-value |
|---|---|---|---|
| Survival No (%) | 68/76 (91.5) | 1200/1418 (87) | 0.22 |
| Survival without severe mordidityb No (%) | 56/73 (81.4) | 870/1341 (69.3) | 0.028 |
| Among survivorsb | |||
| Severe cerebral lesion No (%) | 7/65 (9.1) | 80/1189 (6.1) | 0.30 |
| Necrotizing enterocolitis No (%) | 2/67 (2.1) | 44/1186 (3.9) | 0.39 |
| Severe bronchopulmonary dysplasia No (%) | 1/67 (1.2) | 143/1146 (10.1) | 0.008 |
| Severe retinopathy of prematurity No (%) | 0/59 | 23/942 | 0.17 |
a n are crude and % are weighted
b Denominators are lower than the total number of patients in each group, due to missing data
Severe morbidity was defined as severe bronchopulmonary dysplasia, necrotizing enterocolitis, severe retinopathy of prematurity or any of the following severe cerebral abnormalities on cranial ultrasonography: intraventricular hemorrhage with ventricular dilatation or intraparenchymal hemorrhage, or cystic periventricular leukomalacia.