Table 4. Multivariate analysis of neonatal factors associated with a premedication across centers that performed at least one premedication in the DR.
| Risk factors (n with available data) | No. of neonates | Crude analysis (n = 360) | Multivariate analysis (n = 335) | ||||
|---|---|---|---|---|---|---|---|
| Premedicated (n = 76) | Non-premedicated (n = 284) | OR (95% CI) | P-value | Adjusted OR (95% CI) | P-value | ||
|
GA categories (weeks) No. (%) (n = 360) |
|||||||
| 32–34 | 13 | 4 (30.8) | 9 (69.2) | Reference | Reference | ||
| 27–31 | 250 | 67 (26.7) | 183 (73.3) | 0.82 (0.24–2.86) | 0.760 | 0.69 (0.20–2.27) | 0.519 |
| 22–26 | 97 | 5 (5.2) | 92 (94.8) | 0.12 (0.02–0.66) | 0.015 | 0.10 (0.03–0.42) | 0.001 |
| IUGR, No. (%)a (n = 360) | |||||||
| No | 318 | 67 (24.7) | 251 (75.3) | Reference | Reference | ||
| Yes | 42 | 9 (16.7) | 33 (83.3) | 0.84 (0.57–1.25) | 0.389 | 0.77 (0.37–1.28) | |
| 1 min Apgar score b (n = 353) | 353 | 7.3 (2.6) | 5.3 (3.0) | 1.16 (1.07–1.26) | < .001 | 1.14 (1.05–1.25) | 0.002 |
| Maternal general anesthesia, No. (%)a (n = 349) | |||||||
| No | 299 | 68 (25.9) | 231 (74.1) | Reference | Reference | ||
| Yes | 50 | 7 (13.0) | 43 (87.0) | 0.52 (0.18–1.50) | 0.225 | 0.57 (0.20–1.64) | 0.295 |
| Period of birth, No. (%)a (n = 352) | |||||||
| Night | 192 | 32 (17.6) | 160 (82.4) | Reference | Reference | ||
| Day | 160 | 41 (29.3) | 119 (70.7) | 1.64 (0.59–4.57) | 0.349 | 1.68 (0.57–4.97) | 0.347 |
a n are crude and % are weighted,
b mean (SD) weighted.
Abbreviations: IUGR, intra-uterine growth retardation; OR, odds ratio; CI, confidence interval