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. 2016 Sep 12;2016(9):CD011567. doi: 10.1002/14651858.CD011567.pub2

Comparison 1. Antidepressants versus benzodiazepines.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Failure to respond 2 215 Risk Ratio (M‐H, Random, 95% CI) 0.99 [0.67, 1.47]
1.1 TCAs versus BDZs 1 61 Risk Ratio (M‐H, Random, 95% CI) 1.03 [0.63, 1.67]
1.2 SSRIs versus BDZs 1 154 Risk Ratio (M‐H, Random, 95% CI) 0.93 [0.48, 1.80]
1.3 MAOIs versus BDZs 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
1.4 SNRIs versus BDZs 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
1.5 NaSSAs versus BDZs 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
1.6 NDRIs versus BDZs 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
1.7 NRIs versus BDZs 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
1.8 Other ADs versus BDZs 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
2 Total number of dropouts 7 1449 Risk Ratio (M‐H, Random, 95% CI) 1.64 [1.03, 2.63]
2.1 TCAs versus BDZs 6 1295 Risk Ratio (M‐H, Random, 95% CI) 1.67 [0.93, 2.99]
2.2 SSRIs versus BDZs 1 154 Risk Ratio (M‐H, Random, 95% CI) 1.71 [1.03, 2.84]
2.3 MAOIs versus BDZs 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
2.4 SNRIs versus BDZs 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
2.5 NaSSAs versus BDZs 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
2.6 NDRIs versus BDZs 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
2.7 NRIs versus BDZs 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
2.8 Other ADs versus BDZs 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
3 Failure to remit 3 1002 Risk Ratio (M‐H, Random, 95% CI) 1.18 [1.01, 1.37]
3.1 TCAs versus BDZs 2 848 Risk Ratio (M‐H, Random, 95% CI) 1.19 [1.00, 1.41]
3.2 SSRIs versus BDZs 1 154 Risk Ratio (M‐H, Random, 95% CI) 1.12 [0.79, 1.59]
3.3 MAOIs versus BDZs 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
3.4 SNRIs versus BDZs 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
3.5 NaSSAs versus BDZs 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
3.6 NDRIs versus BDZs 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
3.7 NRIs versus BDZs 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
3.8 Other ADs versus BDZs 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
4 Panic symptoms ‐ endpoint score 3 1144 Mean Difference (IV, Random, 95% CI) ‐0.13 [‐1.06, 0.80]
4.1 TCAs versus BDZs 2 998 Mean Difference (IV, Random, 95% CI) ‐0.25 [‐1.72, 1.22]
4.2 SSRIs versus BDZs 1 146 Mean Difference (IV, Random, 95% CI) 0.10 [‐0.34, 0.54]
4.3 MAOIs versus BDZs 0 0 Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
4.4 SNRIs versus BDZs 0 0 Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
4.5 NaSSAs versus BDZs 0 0 Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
4.6 NDRIs versus BDZs 0 0 Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
4.7 NRIs versus BDZs 0 0 Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
4.8 Other ADs versus BDZs 0 0 Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
5 Panic symptoms ‐ mean change 1 44 Mean Difference (IV, Random, 95% CI) 0.40 [‐0.83, 1.63]
5.1 TCAs versus BDZs 1 44 Mean Difference (IV, Random, 95% CI) 0.40 [‐0.83, 1.63]
5.2 SSRIs versus BDZs 0 0 Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
5.3 MAOIs versus BDZs 0 0 Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
5.4 SNRIs versus BDZs 0 0 Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
5.5 NaSSAs versus BDZs 0 0 Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
5.6 NDRIs versus BDZs 0 0 Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
5.7 NRIs versus BDZs 0 0 Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
5.8 Other ADs versus BDZs 0 0 Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
6 Frequency of panic attacks 7 595 Mean Difference (IV, Random, 95% CI) 0.33 [‐0.72, 1.38]
6.1 TCAs versus BDZs 6 458 Mean Difference (IV, Random, 95% CI) 0.30 [‐0.81, 1.41]
6.2 SSRIs versus BDZs 1 137 Mean Difference (IV, Random, 95% CI) 1.20 [‐3.31, 5.71]
6.3 MAOIs versus BDZs 0 0 Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
6.4 SNRIs versus BDZs 0 0 Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
6.5 NaSSAs versus BDZs 0 0 Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
6.6 NDRIs versus BDZs 0 0 Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
6.7 NRIs versus BDZs 0 0 Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
6.8 Other ADs versus BDZs 0 0 Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
7 Agoraphobia 5 1061 Std. Mean Difference (IV, Random, 95% CI) 0.04 [‐0.08, 0.16]
7.1 TCAs versus BDZs 4 949 Std. Mean Difference (IV, Random, 95% CI) 0.04 [‐0.08, 0.17]
7.2 SSRIs versus BDZs 1 112 Std. Mean Difference (IV, Random, 95% CI) 0.0 [‐0.37, 0.37]
7.3 MAOIs versus BDZs 0 0 Std. Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
7.4 SNRIs versus BDZs 0 0 Std. Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
7.5 NaSSAs versus BDZs 0 0 Std. Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
7.6 NDRIs versus BDZs 0 0 Std. Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
7.7 NRIs versus BDZs 0 0 Std. Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
7.8 Other ADs versus BDZs 0 0 Std. Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
8 General anxiety 8 1365 Std. Mean Difference (IV, Random, 95% CI) 0.06 [‐0.25, 0.37]
8.1 TCAs versus BDZs 7 1238 Std. Mean Difference (IV, Random, 95% CI) 0.08 [‐0.28, 0.45]
8.2 SSRIs versus BDZs 1 127 Std. Mean Difference (IV, Random, 95% CI) ‐0.08 [‐0.42, 0.27]
8.3 MAOIs versus BDZs 0 0 Std. Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
8.4 SNRIs versus BDZs 0 0 Std. Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
8.5 NaSSAs versus BDZs 0 0 Std. Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
8.6 NDRIs versus BDZs 0 0 Std. Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
8.7 NRIs versus BDZs 0 0 Std. Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
8.8 Other ADs versus BDZs 0 0 Std. Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
9 Depression 6 892 Std. Mean Difference (IV, Random, 95% CI) ‐0.14 [‐0.29, 0.02]
9.1 TCAs versus BDZs 5 765 Std. Mean Difference (IV, Random, 95% CI) ‐0.08 [‐0.22, 0.06]
9.2 SSRIs versus BDZs 1 127 Std. Mean Difference (IV, Random, 95% CI) ‐0.46 [‐0.81, ‐0.11]
9.3 MAOIs versus BDZs 0 0 Std. Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
9.4 SNRIs versus BDZs 0 0 Std. Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
9.5 NaSSAs versus BDZs 0 0 Std. Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
9.6 NDRIs versus BDZs 0 0 Std. Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
9.7 NRIs versus BDZs 0 0 Std. Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
9.8 Other ADs versus BDZs 0 0 Std. Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
10 Social functioning 4 1007 Std. Mean Difference (IV, Random, 95% CI) 0.16 [‐0.12, 0.44]
10.1 TCAs versus BDZs 3 882 Std. Mean Difference (IV, Random, 95% CI) 0.23 [0.03, 0.42]
10.2 SSRIs versus BDZs 1 125 Std. Mean Difference (IV, Random, 95% CI) ‐0.22 [‐0.57, 0.13]
10.3 MAOIs versus BDZs 0 0 Std. Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
10.4 SNRIs versus BDZs 0 0 Std. Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
10.5 NaSSAs versus BDZs 0 0 Std. Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
10.6 NDRIs versus BDZs 0 0 Std. Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
10.7 NRIs versus BDZs 0 0 Std. Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
10.8 Other ADs versus BDZs 0 0 Std. Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
11 Quality of life 0 0 Std. Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
11.1 TCAs versus BDZs 0 0 Std. Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
11.2 SSRIs versus BDZs 0 0 Std. Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
11.3 MAOIs versus BDZs 0 0 Std. Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
11.4 SNRIs versus BDZs 0 0 Std. Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
11.5 NaSSAs versus BDZs 0 0 Std. Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
11.6 NDRIs versus BDZs 0 0 Std. Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
11.7 NRIs versus BDZs 0 0 Std. Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
11.8 Other ADs versus BDZs 0 0 Std. Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
12 Patient satisfaction 0 0 Std. Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
12.1 TCAs versus BDZs 0 0 Std. Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
12.2 SSRIs versus BDZs 0 0 Std. Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
12.3 MAOIs versus BDZs 0 0 Std. Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
12.4 SNRIs versus BDZs 0 0 Std. Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
12.5 NaSSAs versus BDZs 0 0 Std. Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
12.6 NDRIs versus BDZs 0 0 Std. Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
12.7 NRIs versus BDZs 0 0 Std. Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
12.8 Other ADs versus BDZs 0 0 Std. Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
13 Economic costs 0 0 Std. Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
13.1 TCAs versus BDZs 0 0 Std. Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
13.2 SSRIs versus BDZs 0 0 Std. Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
13.3 MAOIs versus BDZs 0 0 Std. Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
13.4 SNRIs versus BDZs 0 0 Std. Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
13.5 NaSSAs versus BDZs 0 0 Std. Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
13.6 NDRIs versus BDZs 0 0 Std. Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
13.7 NRIs versus BDZs 0 0 Std. Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
13.8 Other ADs versus BDZs 0 0 Std. Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
14 Number of dropouts due to adverse effects 3 1002 Risk Ratio (M‐H, Random, 95% CI) 1.72 [1.03, 2.87]
14.1 TCAs versus BDZs 2 848 Risk Ratio (M‐H, Random, 95% CI) 2.10 [1.13, 3.93]
14.2 SSRIs versus BDZs 1 154 Risk Ratio (M‐H, Random, 95% CI) 1.2 [0.55, 2.61]
14.3 MAOIs versus BDZs 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
14.4 SNRIs versus BDZs 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
14.5 NaSSAs versus BDZs 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
14.6 NDRIs versus BDZs 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
14.7 NRIs versus BDZs 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
14.8 Other ADs versus BDZs 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
15 Number of patients experiencing at least one adverse effect 1 154 Risk Ratio (M‐H, Random, 95% CI) 1.03 [0.92, 1.15]
15.1 TCAs versus BDZs 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
15.2 SSRIs versus BDZs 1 154 Risk Ratio (M‐H, Random, 95% CI) 1.03 [0.92, 1.15]
15.3 MAOIs versus BDZs 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
15.4 SNRIs versus BDZs 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
15.5 NaSSAs versus BDZs 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
15.6 NDRIs versus BDZs 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
15.7 NRIs versus BDZs 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
15.8 Other ADs versus BDZs 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]