Comparison 2. TCAs versus benzodiazepines.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Failure to respond	1	61	Risk Ratio (M‐H, Random, 95% CI)	1.03 [0.63, 1.67]
1.1 Imipramine versus BDZs	1	61	Risk Ratio (M‐H, Random, 95% CI)	1.03 [0.63, 1.67]
2 Total number of dropouts	6	1295	Risk Ratio (M‐H, Random, 95% CI)	1.67 [0.93, 2.99]
2.1 Imipramine versus BDZs	5	980	Risk Ratio (M‐H, Random, 95% CI)	1.87 [1.47, 2.37]
2.2 Clomipramine versus BDZs	1	315	Risk Ratio (M‐H, Random, 95% CI)	0.69 [0.49, 0.98]
3 Failure to remit	2	848	Risk Ratio (M‐H, Random, 95% CI)	1.19 [1.00, 1.41]
3.1 Imipramine versus BDZs	2	848	Risk Ratio (M‐H, Random, 95% CI)	1.19 [1.00, 1.41]
4 Panic symptoms ‐ endpoint score	2	998	Mean Difference (IV, Random, 95% CI)	‐0.25 [‐1.72, 1.22]
4.1 Imipramine versus BDZs	1	777	Mean Difference (IV, Random, 95% CI)	0.5 [0.21, 0.79]
4.2 Clomipramine versus BDZs	1	221	Mean Difference (IV, Random, 95% CI)	‐1.00 [‐1.37, ‐0.63]
5 Panic symptoms ‐ mean change	1	44	Mean Difference (IV, Random, 95% CI)	0.40 [‐0.83, 1.63]
5.1 Imipramine versus BDZs	1	44	Mean Difference (IV, Random, 95% CI)	0.40 [‐0.83, 1.63]
6 Frequency of panic attacks	6	458	Mean Difference (IV, Random, 95% CI)	0.30 [‐0.81, 1.41]
6.1 Imipramine versus BDZs	5	237	Mean Difference (IV, Random, 95% CI)	0.75 [‐0.44, 1.94]
6.2 Clomipramine versus BDZs	1	221	Mean Difference (IV, Random, 95% CI)	‐1.6 [‐3.17, ‐0.03]
7 Agoraphobia	4	949	Std. Mean Difference (IV, Random, 95% CI)	0.04 [‐0.08, 0.17]
7.1 Imipramine versus BDZs	4	949	Std. Mean Difference (IV, Random, 95% CI)	0.04 [‐0.08, 0.17]
8 General anxiety	7	1238	Std. Mean Difference (IV, Random, 95% CI)	0.08 [‐0.28, 0.45]
8.1 Imipramine versus BDZs	6	1017	Std. Mean Difference (IV, Random, 95% CI)	0.22 [0.10, 0.35]
8.2 Clomipramine versus BDZs	1	221	Std. Mean Difference (IV, Random, 95% CI)	‐0.67 [‐0.94, ‐0.40]
9 Depression	5	765	Std. Mean Difference (IV, Random, 95% CI)	‐0.08 [‐0.22, 0.06]
9.1 Imipramine versus BDZs	5	765	Std. Mean Difference (IV, Random, 95% CI)	‐0.08 [‐0.22, 0.06]
10 Social functioning	3	882	Mean Difference (IV, Random, 95% CI)	0.25 [0.09, 0.42]
10.1 Imipramine versus BDZs	3	882	Mean Difference (IV, Random, 95% CI)	0.25 [0.09, 0.42]
11 Quality of life	0	0	Std. Mean Difference (IV, Random, 95% CI)	0.0 [0.0, 0.0]
12 Patient satisfaction	0	0	Std. Mean Difference (IV, Random, 95% CI)	0.0 [0.0, 0.0]
13 Economic costs	0	0	Std. Mean Difference (IV, Random, 95% CI)	0.0 [0.0, 0.0]
14 Number of dropouts due to adverse effects	2	848	Risk Ratio (M‐H, Random, 95% CI)	2.10 [1.13, 3.93]
14.1 Imipramine versus BDZs	2	848	Risk Ratio (M‐H, Random, 95% CI)	2.10 [1.13, 3.93]
15 Number of patients experiencing at least one adverse effect	0	0	Risk Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]