Comparison 7. SSRIs versus SNRIs.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Failure to respond	2	991	Risk Ratio (M‐H, Random, 95% CI)	0.96 [0.75, 1.23]
2 Total number of dropouts	2	991	Risk Ratio (M‐H, Random, 95% CI)	1.11 [0.74, 1.65]
3 Failure to remit	2	991	Risk Ratio (M‐H, Random, 95% CI)	1.05 [0.91, 1.21]
4 Panic symptoms	2	945	Mean Difference (IV, Random, 95% CI)	‐0.12 [‐0.33, 0.10]
5 Frequency of panic attacks	0	0	Std. Mean Difference (IV, Random, 95% CI)	0.0 [0.0, 0.0]
6 Agoraphobia	1	478	Std. Mean Difference (IV, Random, 95% CI)	0.00 [‐0.19, 0.19]
7 General anxiety	1	478	Mean Difference (IV, Random, 95% CI)	‐0.25 [‐1.83, 1.33]
8 Depression	0	0	Std. Mean Difference (IV, Random, 95% CI)	0.0 [0.0, 0.0]
9 Social functioning	1	478	Mean Difference (IV, Random, 95% CI)	0.15 [‐0.71, 1.01]
10 Quality of life	1	478	Mean Difference (IV, Random, 95% CI)	0.06 [‐2.11, 2.23]
11 Patient satisfaction	0	0	Std. Mean Difference (IV, Random, 95% CI)	0.0 [0.0, 0.0]
12 Economic costs	0	0	Std. Mean Difference (IV, Random, 95% CI)	0.0 [0.0, 0.0]
13 Number of dropouts due to adverse effects	2	991	Risk Ratio (M‐H, Random, 95% CI)	1.86 [0.49, 7.05]
14 Number of patients experiencing at least one adverse effect	2	991	Risk Ratio (M‐H, Random, 95% CI)	0.97 [0.88, 1.08]