Comparison 10. Individual Antidepressants versus another antidepressant within the same class.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Failure to respond	4		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
1.1 Escitalopram versus citalopram	1	255	Risk Ratio (M‐H, Random, 95% CI)	0.92 [0.79, 1.06]
1.2 Fluoxetine versus Citalopram	1	42	Risk Ratio (M‐H, Random, 95% CI)	0.57 [0.20, 1.66]
1.3 Sertraline versus paroxetine	2	546	Risk Ratio (M‐H, Random, 95% CI)	0.97 [0.80, 1.17]
2 Total number of dropouts	5		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
2.1 Escitalopram versus Citalopram	1	255	Risk Ratio (M‐H, Random, 95% CI)	0.80 [0.53, 1.20]
2.2 Fluoxetine versus Citalopram	1	42	Risk Ratio (M‐H, Random, 95% CI)	1.0 [0.07, 14.95]
2.3 Sertraline versus Paroxetine	2	546	Risk Ratio (M‐H, Random, 95% CI)	0.74 [0.55, 0.99]
2.4 Imipramine versus Clomipramine	1	40	Risk Ratio (M‐H, Random, 95% CI)	0.86 [0.35, 2.10]
3 Failure to remit	1	255	Risk Ratio (M‐H, Random, 95% CI)	0.90 [0.71, 1.15]
3.1 Escitalopram versus Citalopram	1	255	Risk Ratio (M‐H, Random, 95% CI)	0.90 [0.71, 1.15]
4 Panic symptoms	3		Std. Mean Difference (IV, Random, 95% CI)	Subtotals only
4.1 Escitalopram versus Citalopram	1	237	Std. Mean Difference (IV, Random, 95% CI)	‐0.09 [‐0.35, 0.16]
4.2 Sertraline versus Paroxetine	2	473	Std. Mean Difference (IV, Random, 95% CI)	‐0.05 [‐0.23, 0.13]
5 Frequency of panic attacks	2		Mean Difference (IV, Random, 95% CI)	Subtotals only
5.1 Sertraline versus Paroxetine	2	461	Mean Difference (IV, Random, 95% CI)	0.48 [‐1.02, 1.98]
6 Agoraphobia	1		Mean Difference (IV, Random, 95% CI)	Subtotals only
6.1 Escitalopram versus Citalopram	1	237	Mean Difference (IV, Random, 95% CI)	‐1.10 [‐3.46, 1.26]
7 General anxiety	3		Mean Difference (IV, Random, 95% CI)	Subtotals only
7.1 Escitalopram versus Citalopram	1	237	Mean Difference (IV, Random, 95% CI)	‐1.20 [‐3.14, 0.74]
7.2 Sertraline versus Paroxetine	2	454	Mean Difference (IV, Random, 95% CI)	‐0.72 [‐2.42, 0.99]
8 Depression	2		Std. Mean Difference (IV, Random, 95% CI)	Subtotals only
8.1 Escitalopram versus Citalopram	1	237	Std. Mean Difference (IV, Random, 95% CI)	‐0.11 [‐0.36, 0.15]
8.2 Sertraline versus Paroxetine	1	189	Std. Mean Difference (IV, Random, 95% CI)	0.00 [‐0.28, 0.29]
9 Social functioning	0	0	Std. Mean Difference (IV, Random, 95% CI)	0.0 [0.0, 0.0]
10 Quality of life	1		Mean Difference (IV, Random, 95% CI)	Subtotals only
10.1 Escitalopram versus Citalopram	1	237	Mean Difference (IV, Random, 95% CI)	1.40 [‐1.51, 4.31]
11 Patient satisfaction	0	0	Std. Mean Difference (IV, Random, 95% CI)	0.0 [0.0, 0.0]
12 Economic costs	0	0	Std. Mean Difference (IV, Random, 95% CI)	0.0 [0.0, 0.0]
13 Number of dropouts due to adverse effects	5		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
13.1 Escitalopram versus Citalopram	1	255	Risk Ratio (M‐H, Random, 95% CI)	0.78 [0.32, 1.92]
13.2 Fluoxetine versus Citalopram	1	42	Risk Ratio (M‐H, Random, 95% CI)	1.0 [0.07, 14.95]
13.3 Sertraline versus Paroxetine	2	546	Risk Ratio (M‐H, Random, 95% CI)	0.66 [0.42, 1.04]
13.4 Imipramine versus Clomipramine	1	40	Risk Ratio (M‐H, Random, 95% CI)	0.33 [0.08, 1.46]
14 Number of patients experiencing at least one adverse effect	2		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
14.1 Escitalopram versus Citalopram	1	255	Risk Ratio (M‐H, Random, 95% CI)	0.95 [0.85, 1.06]
14.2 Sertraline versus Paroxetine	1	321	Risk Ratio (M‐H, Random, 95% CI)	0.99 [0.89, 1.10]