Zhang 2000.

Methods	Study design: Randomised controlled trial
Participants	Diagnosis: DSM III ‐ R Method of diagnosis: no available information Age: no available information Sex: no available information Location: China; setting: in and outpatients Co‐morbidities: none Rescue medication: not stated
Interventions	Participants were randomly assigned to either: (1) paroxetine arm (n = 38) Duration: 10 weeks Treatment Protocol: week 1: 20 mg, week 2: 30 mg, week 3: 40 mg, week 4‐10: 40‐50 mg; M = 43.5, SD = 4.8 (2) clomipramine arm (n = 35) Duration: 10 weeks Treatment Protocol: week 1: 50 mg, week 2: 100 mg, week 3: 150 mg, week 4‐10: 150‐200 mg; M = 159.7, SD = 20.1
Outcomes	Time points for assessment: no available information Outcomes: no available information
Notes	Date of study: no available information Funding source: sponsored by the drug company marketing the drug Declarations of interest among the primary researchers: no available information.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Insufficient information to assess whether an important risk of bias exists.
Allocation concealment (selection bias)	Unclear risk	Insufficient information to assess whether an important risk of bias exists.
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Insufficient information to assess whether an important risk of bias exists.
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Insufficient information to assess whether an important risk of bias exists.
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	Insufficient information to assess whether an important risk of bias exists.
Selective reporting (reporting bias)	Unclear risk	Insufficient information to assess whether an important risk of bias exists.
Other bias	High risk	Sponsored by the drug company marketing the drug; the role of the funder in planning, conducting and writing the study is not discussed.

DSM III/IV: Diagnostic and Statistical Manual of Mental Disorders (third/fourth revision)
 GAD: generalised anxiety disorder
 ICD‐10: International Statistical Classification of Diseases and Related Health Problems, 10th revision
 ITT: intention‐to‐treat
 LOCF: last observation carried forward
 M: mean
 MDD: major depressive disorder
 MHPG: 3‐methoxy‐4‐hydroxyphenylglycol
 OCD: obsessive compulsive disorder
 SCL‐90: Anxiety Subscale of Symptom Checklist‐90‐Revised
 SD: standard deviation
 SEM: standard error of the mean
 TCAs: tricyclic antidepressants