Study	Reason for exclusion
Bakish 1994	Study design (single case).
Baldini Rossi 2000	Participants were not primarily diagnosed with panic disorder.
Balon 1991	Study design (panicogenic).
Balon 1993	Study design (panicogenic).
Bystritsky 1990	Study design (not double‐blind).
Charney 1986	Study design (not randomised).
Davis 1981	Study design (it is not a study).
de Jonghe 1989	Participants were diagnosed with anxiety disorders including panic disorder, but the randomisation was not stratified by diagnosis; wrong comparison (lorazepam versus suriclone).
Dell'Erba 2006	Study design (not randomised); combined therapy with cognitive behaviour therapy.
den Boer 1987	Participants were diagnosed with anxiety disorders including panic disorder, but the randomisation was not stratified by diagnosis.
Dunner 1986	Participants were diagnosed with anxiety disorders including panic disorder, but the randomisation was not stratified by diagnosis.
Dyukova 1992	Study design (not randomised); participants were not diagnosed with panic disorder.
Evans 1986	Combined therapy with psychotherapy.
Fahy 1992	Combined therapy with psychotherapy.
Franulic 1989	Study design (not randomised).
Furukawa 2009	Study design (it is not a study); combined therapy with cognitive behaviour therapy.
Grilo 1998	Combined therapy with cognitive behaviour therapy.
Keller 1993	Participants were not primarily diagnosed with panic disorder.
Lepola 1989	Study design (not randomised).
Mavissakalian 2003	Study design (long‐term phase of a discontinuation/maintenance open‐label study).
McHugh 2007	Combined therapy with cognitive behaviour therapy.
Miretzky 1992	Combined therapy with cognitive behaviour therapy.
Nair 1982	Participants were diagnosed with anxiety disorders including panic disorder, but the randomisation was not stratified by diagnosis.
Nardi 2011	Study design (not double‐blind).
Pareek 2014	Wrong comparison (clonazepam‐CR versus clonazepam).
Pfizer 2002	Wrong comparison (venlafaxine versus placebo).
Pfizer 2005	Study design (not double‐blind).
Pohl 1989	Combined therapy with psychotherapy.
Pollack 2003	Combined therapy with different drugs.
Pyke 1989	Study design (panicogenic).
Raffaele 2002	Wrong comparison (citalopram versus placebo).
Roll 2004	Combined therapy with cognitive behaviour therapy.
Roy‐Byrne 2001	Wrong comparison (paroxetine versus usual care).
Sheehan 1980	Participants were not diagnosed with panic disorder.
Surman 1986	Study design (not randomised).
Svebak 1990	Study design (not randomised).
Tsutsui 2000	Wrong comparison (paroxetine versus placebo).
Tyrer 1988	Participants with different diagnosis, and randomisation was not stratified according to diagnosis.
van Apeldoorn 2008	Combined therapy with cognitive behaviour therapy.
Yang 2005	Study design (not double‐blind).
Yang 2006	Study design (not double‐blind).
Yeragani 1992	Study design (panicogenic).
Zajecka 1996	Participants were not diagnosed with panic disorder.