Macpherson 2013

Methods	Study design: interrupted time series Conducted in: Scotland Unit of randomisation: school Unit of analysis: individual Setting: nurseries participating in national toothbrushing programme Funded by: "Childsmile is funded by the Scottish Government. Data collections were funded by the National Health Service (NHS)"
Participants	Inclusion criteria: not applicable Exclusion criteria: not applicable Age at baseline: 5 years Total number of participants: 99,071 (multiple cross‐sectional dental epidemiological surveys of 5‐year‐old children in Scotland between 1987 and 2009) Recruitment: through nurseries participating in national toothbrushing programme Gender: not reported
Interventions	Intervention: daily supervised toothbrushing in nurseries. Distribution of fluoridate toothpaste through nurseries to encourage home toothbrushing Control: N/A Duration of intervention: 6 years (annual cross‐sectional surveys)
Outcomes	Caries (d3mft)
Implementation related factors	Theoretical basis: national policy Resources for implementation: not published Who delivered the intervention: nursery staff PROGRESS categories assessed at baseline: SES PROGRESS categories analysed at outcome: SES Outcomes related to harms/unintended effects: not reported Intervention included strategies to address diversity or disadvantage: no. Study authors resent findings based on deprivation categories, using Castairs Socio‐economic Deprivation Score (DepCat ‐ DepCAT 1 was the most affluent, and DepCAT 7 the least affluent). In the post‐intervention period for DepCat 6‐7, children’s mean d3mft decreased from 4.48 in the reference period to 2.77 in the period between year 10 and year 12, whereas for DepCat 1‐2, the decrease was less profound – from 1.52 to 1.10 Economic evaluation: not reported
Notes	See Table 10 for Risk of bias table