| Study name
Inclusion and exclusion criteria |
Number of people in intervention group |
Number of people in control group |
Risk of bias |
| Random sequence generation |
Allocation concealment |
Blinding of participants and personnel |
Blinding of outcome assessment |
Incomplete outcome data |
Selective reporting |
Other bias |
| Endoscopic drainage versus EUS guided drainage |
| Park 2009 |
31 |
29 |
Low |
Unclear |
High |
High |
Low |
Low |
Unclear |
|
Inclusion criteria
1. History of pancreatitis.
2. Symptomatic pseudocysts with duration of longer than 4 weeks.
Exclusion criteria
1. Age less than 18 years.
2. A pancreatic pseudocyst more than 4 cm in size and communicating with the pancreatic duct.
3. A suggested pancreatic abscess or necrosis, shown by computed tomography (CT).
4. A moderate thickness (> 10 mm) from the cyst wall to the intramural wall, shown by EUS.
5. Portal hypertension or coagulopathy. |
| Varadarajulu 2008 |
14 |
15 |
Low |
Low |
High |
Unclear |
High |
Low |
Unclear |
|
Inclusion criteria
1. History of pancreatitis.
2. Symptomatic pseudocysts.
Exclusion criteria
1. CT findings were suggestive of pathology other than a pseudocyst.
2. Pseudocyst was ≤ 4 cm in size.
3. Patients younger than 18 years of age.
4. Patients with pancreatic abscess or necrosis by CT. |
| EUS‐guided drainage with nasocystic drainage versus EUS‐guided drainage |
| Yuan 2015 |
23 |
24 |
Unclear |
Low |
Unclear |
Unclear |
Unclear |
High |
Unclear |
|
Inclusion criteria
1. Ages 16 to 70 years.
2. Clinical presentation with abdominal distension with or without upper gastrointestinal obstruction.
3. Radiological findings suggestive of a pancreatic pseudocyst > 10 cm.
Exclusion criteria
1. Cysts without adherence to the gastric wall.
2. Distance between pseudocyst and gastric wall greater than 1 cm.
3. Pseudocyst communication with the main pancreatic duct.
4. Pregnancy.
5. Pancreatic tumors.
6. Risk for anaesthesia and surgery.
7. Contraindications to magnetic resonance cholangiopancreatography and endoscopic retrograde cholangiopancreatography.
8. Liver cirrhosis.
9. Previous history of abdominal surgery (e.g. gastrectomy).
10. Inability to give informed consent. |
| Open surgical drainage versus EUS‐guided drainage |
| Varadarajulu 2013 |
20 |
20 |
Low |
Low |
High |
High |
Low |
Low |
Low |
|
Inclusion criteria
1. Diagnosis of pancreatic pseudocyst based on CT criteria.
2. Pseudocyst measuring >= 6 cm in size and located adjacent to the stomach.
3. Documented history of acute or chronic pancreatitis.
4. Persistent pancreatic pain requiring narcotics or analgesics.
5. Symptomatic gastric outlet or bile duct obstruction induced by the pseudocyst.
Exclusion criteria
1. Age < 18 or > 80 years.
2. Contraindications to surgery: ASA class IV, severe portal hypertension.
3. Contraindication to endoscopic drainage: gastrectomy with Billroth II reconstruction, gastric bypass surgery, prior surgery for pancreas‐related complications.
4. Pregnancy.
5. Associated pancreatic necrosis on CT.
6. Pseudocyst not adjacent to the stomach.
7. Multiloculated pseudocyst or multiple pseudocysts. |
