| Study | Reason for exclusion |
|---|---|
| Ashworth 2008 | Review article |
| Audeh 2009 | Phase II, single‐arm trial of the oral PARP inhibitor OLA (AZD2281) in BRCA‐deficient advanced ovarian cancer (ASCO 2009 meeting abstract) |
| Audeh 2010 | Non‐randomised, phase II, single‐arm study (update of Audeh 2009) |
| Banerjee 2013 | Review article |
| Chen 2013 | Review article |
| Coleman 2014 | Non‐randomised phase II trial; no control group |
| Drew 2008 | Review article |
| Fong 2006 | Phase I pharmacokinetic (PK) and pharmacodynamic (PD) evaluation of a small molecule inhibitor of Poly(ADP‐ribose) polymerase (PARP), KU‐0059436 (Ku) in patients with advanced tumours (ASCO 2006 meeting abstract) |
| Fong 2008 | Results from a phase I study of AZD2281 (KU‐0059436), a PARP (poly(ADP‐ribose) polymerase) inhibitor with single‐agent anticancer activity in patients with BRCA‐deficient ovarian cancer (ASCO 2008 meeting abstract) |
| Fong 2009 | Non‐randomised phase I clinical trial analysing the pharmacokinetic and pharmacodynamic characteristics of OLA (AZD2281). Selection was aimed at having a study population enriched in carriers of a BRCA1 or BRCA2 mutation |
| Gelmon 2011 | Phase 2, multicentre, open‐label, non‐randomised study |
| Helleday 2008 | Review article |
| Lee 2014 | Biomarker study of RCT comparing olaparib plus/minus cediranib: wrong comparison and wrong outcomes |
| Lord 2008 | Review article |
| Lui 2014 | Comparison of Olaparib versus Olaparib and Cediranib ‐ no randomisation of Olaparib; 2 references to this study. |
| Moore 2014 | On‐going study but study on effects of high fat food on pharmacokinetics |
| Muggia 2009 | Review article |
| NCT01891344 | Ongoing, non‐randomised, open‐label, phase II study (Ariel2) |
| Shaw 2013 | Review article |
| Turner 2005 | Review article |
| Yap 2007 | Phase I pharmacokinetic (PK) and pharmacodynamic (PD) study of KU‐0059436 (Ku), a small molecule inhibitor of poly(ADP‐ribose) polymerase (PARP) in cancer patients, including BRCA1/2 mutation carriers (ASCO 2007 meeting abstract) |
| Yap 2009 | Review article |
OLA: olaparib