Study | Reason for exclusion |
---|---|
Ashworth 2008 | Review article |
Audeh 2009 | Phase II, single‐arm trial of the oral PARP inhibitor OLA (AZD2281) in BRCA‐deficient advanced ovarian cancer (ASCO 2009 meeting abstract) |
Audeh 2010 | Non‐randomised, phase II, single‐arm study (update of Audeh 2009) |
Banerjee 2013 | Review article |
Chen 2013 | Review article |
Coleman 2014 | Non‐randomised phase II trial; no control group |
Drew 2008 | Review article |
Fong 2006 | Phase I pharmacokinetic (PK) and pharmacodynamic (PD) evaluation of a small molecule inhibitor of Poly(ADP‐ribose) polymerase (PARP), KU‐0059436 (Ku) in patients with advanced tumours (ASCO 2006 meeting abstract) |
Fong 2008 | Results from a phase I study of AZD2281 (KU‐0059436), a PARP (poly(ADP‐ribose) polymerase) inhibitor with single‐agent anticancer activity in patients with BRCA‐deficient ovarian cancer (ASCO 2008 meeting abstract) |
Fong 2009 | Non‐randomised phase I clinical trial analysing the pharmacokinetic and pharmacodynamic characteristics of OLA (AZD2281). Selection was aimed at having a study population enriched in carriers of a BRCA1 or BRCA2 mutation |
Gelmon 2011 | Phase 2, multicentre, open‐label, non‐randomised study |
Helleday 2008 | Review article |
Lee 2014 | Biomarker study of RCT comparing olaparib plus/minus cediranib: wrong comparison and wrong outcomes |
Lord 2008 | Review article |
Lui 2014 | Comparison of Olaparib versus Olaparib and Cediranib ‐ no randomisation of Olaparib; 2 references to this study. |
Moore 2014 | On‐going study but study on effects of high fat food on pharmacokinetics |
Muggia 2009 | Review article |
NCT01891344 | Ongoing, non‐randomised, open‐label, phase II study (Ariel2) |
Shaw 2013 | Review article |
Turner 2005 | Review article |
Yap 2007 | Phase I pharmacokinetic (PK) and pharmacodynamic (PD) study of KU‐0059436 (Ku), a small molecule inhibitor of poly(ADP‐ribose) polymerase (PARP) in cancer patients, including BRCA1/2 mutation carriers (ASCO 2007 meeting abstract) |
Yap 2009 | Review article |
OLA: olaparib