| Study | Reason for exclusion |
|---|---|
| Abraira 1998 | Mixed population: insulin‐naive and previously insulin‐treated |
| Al‐Shaikh 2006 | Insulin‐naive participants |
| Altuntas 2003 | Insulin‐naive participants |
| Bachman 1988 | Insulin‐naive participants |
| Barranco 2006 | No insulin therapy arm |
| Berhanu 2007 | Impossible to analyse subgroup of insulin‐users separately |
| Bianchi 1996 | Trial on combination of benfluorex with insulin |
| Buse 1998 | Use of troglitazone (off the market) |
| Carta 1984 | Insulin‐naive participants |
| Castillo 1987 | Insulin‐naive participants |
| Charbonnel 2010 | Impossible to analyse subgroup of insulin‐users separately |
| Chazan 2001 | Insulin‐naive participants |
| Chow1995 | Insulin‐naive participants |
| Clauson 1995 | Insulin‐naive participants |
| Cortes 1993 | Well‐controlled population |
| Dashora 2007 | Impossible to analyse subgroup of insulin‐users separately |
| Davidson 2006 | No arm without oral agent or placebo |
| De Luis 2001 | No RCT |
| Douek 2005 | Insulin‐naive participants |
| Fonseca 2006 | Insulin‐naive participants |
| Fonseca 2008 | Observational phase of RCT |
| Garg 2007 | No RCT |
| Gerstein 2006 | Insulin‐naive participants |
| Goudswaard 2004a | Insulin‐naive participants |
| Greco 1998 | No RCT |
| Groop 1984 | Insulin‐naive participants |
| Groop 1991 | Insulin‐naive participants |
| Gutniak 1987 | Insulin‐naive participants |
| Hamelbeck 1982 | Insulin‐naive participants |
| Hermanns 2004 | Follow‐up less than 2 months |
| Hollander 2003 | Adding of non‐oral agent pramlintide |
| Hollander 2003a | Adding of non‐oral agent pramlintide |
| Hollander 2004 | Adding of non‐oral agent pramlintide |
| Hollander 2007 | Adding of rosiglitazone (off the market) |
| Holman 1987 | Insulin‐naive participants |
| Home 2007 | Insulin‐naive participants |
| Inoue1998 | Insulin‐naive participants |
| Jacob 2007 | Impossible to analyse subgroup of insulin‐users separately |
| Jacober 2006 | Insulin‐naive participants |
| Janka 2005 | Insulin‐naive participants |
| Janka 2007 | Insulin‐naive participants |
| Juurinen 2008 | No RCT |
| Juurinen 2009 | Impossible to analyse subgroup of insulin‐users separately |
| Kabadi 2003 | Insulin‐naive participants |
| Kanda 1996 | Insulin‐naive participants |
| Kandalintseva 2008 | Rosiglitazone combination therapy (off the market) |
| Karlander 1991 | Insulin‐naive participants |
| Kilo 2003 | Insulin‐naive participants |
| Kokic 2003 | Insulin‐naive participants |
| Kothny 2013 | Impossible to analyse subgroup of insulin‐users separately |
| Kvapil 2006 | Insulin‐naive participants |
| LAPToP 2004 | Insulin‐naive participants |
| Lins 1988 | Insulin‐naive participants |
| Liu 2003 | Rosiglitazone combination therapy (off the market) |
| Lotz 1988 | Insulin‐naive participants |
| Lund 2009 | Insulin‐naive participants |
| Lundershausen 1987 | Insulin‐naive participants |
| Makimattila 1999 | Insulin‐naive participants |
| Mohan 1990 | No RCT |
| Morrow 2011 | Combination with ligarglutide (non‐oral agent) |
| Olsson 2002 | Insulin‐naive participants |
| Ose 2005 | Not RCT |
| Ozbek 2006 | Well‐controlled population |
| Pan 2007 | Insulin‐naive participants |
| Peacock 1984 | Insulin‐naive participants |
| Peyrot 2008 | Addition of a non‐oral agent pramlintide |
| Ponssen 2000 | Mixed group: insulin‐naive and previously insulin‐treated participants |
| Pontiroli 1990 | Insulin‐naive participants |
| Poulsen 2003 | Control group mixed: insulin‐ and insulin + metformin‐treated |
| Raskin 2001 | Addition of rosiglitazone (off the market) |
| Ravnik 1989 | Insulin‐naive participants |
| Ravnik 1995 | Insulin‐naive participants |
| Raz 2005 | Insulin‐naive participants |
| Riddle 1989 | Mixed group: insulin‐naive and previously insulin‐treated participants |
| Riddle 1992 | Insulin‐naive participants |
| Riddle 1998 | Insulin‐naive participants |
| Riddle 2007 | Adding of a non‐oral agent pramlintide |
| Rosak 1985 | Follow‐up less than 2 months |
| Sachse 1984 | Insulin‐naive participants |
| Sangiorgio 2000 | Not RCT |
| Schmidt 1986 | Insulin‐naive participants |
| Schnell 2006 | Insulin‐naive participants |
| Schwartz 1998 | Use of troglitazone (off the market) |
| Sun 1995 | Insulin‐naive participants |
| Tamemoto 2007 | Insulin‐naive participants |
| Vilsboll 2010 | Impossible to analyse subgroup of insulin‐users separately |
| Willey 1994 | Mixed group: insulin‐ and insulin + metformin‐treated participants; trial on combination of insulin and dexfenfluramine |
| Wolffenbuttel 1991 | Insulin‐naive participants |
| Wolffenbuttel 1999 | Insulin‐naive participants |
| Wong 2005 | Special population: type 2 diabetes participants with peritoneal dialysis |
| Wright 2002 | Newly diagnosed type 2 diabetes participants |
| Yamada 2007 | No arm without oral agent or placebo |
| Yki‐Jarvinen 1992 | Insulin‐naive participants |
| Yki‐Jarvinen 1999 | Insulin‐naive participants |
| Yki‐Jarvinen 2013 | Impossible to analyse subgroup of insulin‐users separately |
| Yokoyama 2011 | Two arms: continuation and discontinuation of glimepiride |
| Zargar 2002 | Insulin‐naive participants |
RCT: randomised controlled trial