| Methods |
Multicenter, randomised, double‐blind, placebo‐controlled, 24‐week clinical trial |
| Participants |
660 participants with type 2 diabetes and inadequate glycaemic control on insulin, with or without metformin (> 1500 mg/day) or sulfonylurea, for > 10 weeks. Participants could remain on metformin but not sulphonylurea after randomisation |
| Interventions |
Sitagliptin 100 mg/day or placebo was administered concurrently with insulin glargine titration, targeting a fasting glucose of 4.0‐5.6 mmol/L (72‐100 mg/dL) |
| Outcomes |
Insulin dose, HbA1c, hypoglycaemia, adverse effects |
| Notes |
Subgroup analysis with insulin monotherapy needs to be checked |
