Comparison 3. Topiramate vs an alternative drug as monotherapy.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Efficacy of topiramate as monotherapy in the treatment of manic and mixed episodes. Change in mean scores from baseline to endpoint (12 weeks) on symptom rating scales (negative numbers indicate improvement)	2	449	Mean Difference (IV, Random, 95% CI)	8.46 [5.86, 11.06]
2 Acceptability with topiramate as monotherapy. Number of participants experiencing troublesome side effects of any nature (12 weeks)	1		Odds Ratio (M‐H, Random, 95% CI)	Totals not selected