Aoyama 2006

Methods	RCT enrolled: 160 evaluated: 132
Participants	Inclusion: 1. 1‐ 4 brain metastases 2. size ≤ 3 cm 3. pathologically confirmed systemic cancer Exclusion: 1. History of brain irradiation or surgery 2. small cell cancer, lymphoma, germinoma, myeloma, non‐melanomatous skin cancer
Interventions	Radiosurgery alone versus WBRT and radiosurgery
Outcomes	1. Overall survival 2. Cause of death 3. Proportion with KPS ≥ 70 4. Neurologic functional preservation rate 5. Freedom from metachronous brain metastases 6. Freedom from new brain metastases 7. Salvage treatment for new/recurrent brain metastases 8. Local tumor control rate
Notes