Borgelt 1980

Methods	RCT (2 studies) study 1: enrolled: 993 evaluated: 910 study 2: enrolled: 1001 evaluated: 902
Participants	Inclusion: 1. Brain metastases by clinical symptoms, EEG, radioisotope brain scans, arteriogram, pneumoencephalogram, biopsy Exclusion: 1. General medical or neoplastic status prohibiting adequate assessment 2. Other cancer treatment within two weeks of entry 3. Lesions too numerous or symptoms too vague for follow up
Interventions	study 1: 4000 cGy/20 fr (227 pts) versus 4000 cGy/15 fr (233 pts) versus 3000 cGy/15 fr (217 pts) versus 3000 cGy/10 fr (233 pts) study 2: 4000 cGy/15 fr (227 pts) versus 3000 cGy/10 fr (228 pts) versus 2000 cGy/5 fr (447 pts)
Outcomes	1. Survival 2. Palliative index
Notes	QS = 2