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Eyre 1984
| Methods | RCT: enrolled: 116 evaluated: 111 | |
| Participants | Inclusion: 1. Histological proof of malignancy 2. Clinical documentation of brain mets (isotope or CT) 3. Neurologic symptoms 4. No prior cranial radiation 5. Expected survival more than 4 wks 6. Adults Exclusion: 1. Systemic chemotherapy with agents that cross blood brain barrier |
|
| Interventions | 3000 cGy/10 fr and metronidazole versus 3000 cGy/10 fr | |
| Outcomes | 1. Survival 2. Response rates (CR + PR) | |
| Notes | QS = 2 | |
