Guerrieri 2004

Methods	RCT: planned sample: 300 closed due to poor accrual: 42
Participants	Inclusion: 1. metastatic NSCLC to brain 2. inoperable CNS disease or refused surgery 3. WHO performance status zero to two 4. adequate blood counts 5. urinary creatinine ≥ 50 mL/min Exclusion: 1. Prior chemotherapy 2. Prior brain radiotherapy
Interventions	2000 cGy/5 fr versus 2000 cGy/5 fr and carboplatin
Outcomes	1. Overall survival 2. Radiographic brain response 3. Symptom control 4. Toxicity
Notes	QS = 1