Knisely 2008

Methods	RCT enrolled: 332 evaluated: 183
Participants	18 years of age or older anticipated survival more than 8 weeks Zubrod performance status of 0‐1 MRI documented brain metastases histologically proven extracranial solid tumour not eligible for radiosurgery (due to size more than 4 cm, number more than 3 or location eg. midbrain)
Interventions	whole brain radiotherapy versus whole brain radiotherapy and thalidomide
Outcomes	primary: survival secondary: central nervous system progression rates toxicity
Notes