Lee 2008

Methods	RCT enrolled: 48 evaluated: 48
Participants	pathologically confirmed nonsmall cell lung cancer clinically silent brain metastases (not surgically resectable) age 18‐75 years ECOG performance status 0‐3 adequate bone marrow, hepatic, renal functions no prior chemotherapy nor molecular‐targeted therapy
Interventions	chemotherapy first followed by whole brain radiation versus whole brain radiation followed by chemotherapy
Outcomes	progression‐free survival tumour response quality of life toxicity
Notes