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Neuhaus 2009
| Methods | RCT enrolled: 96 evaluated: 96 |
|
| Participants | histologically proven lung cancer (small cell or nonsmall cell) 18‐75 years of age at least one measurable lesion in the brain sufficient bone marrow reserve, renal function tests ECOG performance status 0‐2 excluded leptomeningeal metastases |
|
| Interventions | whole brain radiation alone versus whole brain radiation and topotecan |
|
| Outcomes | response rate progression‐free survival overall survival quality of life |
|
| Notes | ||
