Scott 2007

Methods	RCT enrolled: 538 (non‐small cell lung cancer, breast cancer and other primaries) evaluated: 106 (subgroup of breast cancer)
Participants	brain metastases RTOG recursive partitioning analysis (class I or II) no prior treatment of brain metastases (except partial resection allowed) chemotherapy discontinued at least 7 days prior to the start of whole brain radiotherapy and not to be restarted until at least 1 month after whole brain radiotherapy excluded small cell lung cancer, germ cell tumours and lymphomas
Interventions	whole brain radiotherapy versus whole brain radiotherapy and efaproxiral
Outcomes	Primary: overall survival Secondary: quality of life
Notes	subgroup analysis (not a priori)