Ushio 1991

Methods	RCT enrolled: 100 evaluated: 88
Participants	Inclusion: 1. brain metastases from lung cancer 2. extracranial cancer relatively well controlled 3. good general condition
Interventions	WBRT versus WBRT + chloroethylnitrosoureas versus WBRT + chloroethylnitrosoureas + tegafur
Outcomes	1. Response rates 2. Survival
Notes	QS = 2

CNS = Central Nervous System CR = complete response CT = computed tomography ECOG = Eastern Co‐operative Oncology Group EEG = electroencephalography KPS = Karnofsky performance status MRC = Medical Research Council NFC = neurologic functional classification NSCLC = non‐small cell lung cancer PR = partial response QS = quality score RCT = randomized controlled trial RPA = recursive partitioning analysis RT = radiotherapy y.o. = years old WBC = white blood count WBRT = whole brain radiotherapy