Date	Event	Description
8 March 2012	New search has been performed	New search conducted on 19 July 2011.
6 March 2012	New citation required but conclusions have not changed	This update does not provide substantive changes to the original review. The title has been amended to: Whole brain radiotherapy for the treatment of newly diagnosed multiple brain metastases. The descriptor 'newly diagnosed' was added to clarify that the review only deals with upfront management rather than management at relapse. The literature search was updated in July 2011. Nine new trials (Chang 2009, Davey 2008, Graham 2010, Knisely 2008, Kocher 2011, Lee 2008, Neuhaus 2009, Scott 2007, Suh 2008) involving 1420 participants were added to this updated review. This updated review now includes a total of 39 trials involving 10,835 participants. The statistical analyses have now been revised. Hazard ratios (rather than odds ratios) are now provided for the outcomes of overall survival, local control and distant brain control. Risk ratios with 95% CI were recalculated with formal statistical input for the outcomes of neurologic function improvement and brain tumour response. In terms of implications for practice, the option of radiosurgery alone (without WBRT) in selected patients with newly diagnosed brain metastases has been added.