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. 2012 Apr 18;2012(4):CD003869. doi: 10.1002/14651858.CD003869.pub3

Andrews 2004

Methods RCT enrolled: 333 evaluated: 331
Participants Inclusion: 1. 1‐3 brain metastases 2. maximum size 4 cm (largest lesion) and others not more than 3 cm Exclusion: 1. KPS < 70 2. brainstem metastasis 3. metastasis less than 1 cm from optic apparatus 4. active extracranial disease judged by systemic treatment given within 1 month of enrollment
Interventions WBRT and radiosurgery boost vs WBRT
Outcomes 1. Overall survival 2. Local control, overall intracranial recurrence rates 3. cause of death 4. performance status 5. steroid usage
Notes QS = 3