Study ID	Treatment	Analgesia			Rescue medication
		PI or PR	Number with 50% PR	PGE: very good or excellent	Median time to use (95% CI) (h)	Number using
McQuay 2016	(1) Dkp/Tram 25/75 mg (2) Dkp 25 mg (3) Tram 100 mg (4) Placebo	TOTPAR 6 (SD): (1) 13 (5.4) (2) 12 (5.2) (3) 12 (5.2) (4) 10 (5.2)	TOTPAR 6 h responders: (1) 61% = 97/159 (2) 57% = 92/161 (3) 54% = 86/160 (4) 41% = 66/161	At 8 h: (1) 56/159 (2) 44/161 (3) 51/160 (4) 18/161	Not calculable > 8 h	No data for single dose phase
Moore 2015	(1) Dkp/tram 12.5/37.5 mg (2) Dkp/tram 12.5/75 mg (3) Dkp/tram 25/37.5 mg (4) Dkp/tram 25/75 mg (5) Dkp 12.5 mg (6) Dkp 25 mg (7) Tram 37.5 mg (8) Tram 75 mg (9) Ibu 400 mg (10) Placebo	TOTPAR 6 (SD): (1) 10.2 (5.5) (2) 13.3 (7.0) (3) 12.6 (6.6) (4) 14.5 (6.1) (5) 7.9 (5.9) (6) 11.8 (5.6) (7) 4.0 (4.5) (8) 5.4 (6.1) (9) 10.5 (7.2) (10) 2.9 (4.8)	TOTPAR 6 h responders: (1) 22/60 (2) 37/62 (3) 35/63 (4) 44/61 (5) 16/60 (6) 33/60 (7) 6/59 (8) 15/59 (9) 27/60 (10) 6/62	At end of assessment period (24 h) (1) 27% = 16/60 (2) 46% = 29/62 (3) 46% = 29/63 (4) 51% = 31/61 (5) 33% = 20/60 (6) 28% = 17/60 (7) 9% = 5/59 (8) 14% = 8/59 (9) 33% = 20/60 (10) 5% = 3/62	Median (1) 4.9 (4.0 to 5.8) (2) 8.5 (5.9 to 13) (3) 7.3 (6.3 to 9.0) (4) 8.1 (6.3 to 13) (5) 3.6 (2.7 to 4.3) (6) 5.6 (4.8 to 7.6) (7) 2.2 (1.3 to 3.0) (8) 2.5 (1.4 to 3.9) (9) 7.1 (4.8 to 8.6) (10) 1.4 (1.2 to 1.8)	At 6 h: (1) 40/60 (2) 29/62 (3) 25/63 (4) 23/61 (5) 39/60 (6) 36/60 (7) 41/59 (8) 38/59 (9) 29/60 (10) 45/62
Moore 2016	(1) Dkp/tram 25/75 mg (2) Dkp 25 mg (3) Tram 100 mg (4) Placebo	TOTPAR 6 (SD): (1) 14 (4.6) (2) 11 (5.2) (3) 11 (5.5) (4) 8.9 (5.1)	TOTPAR 6 h responders: (1) 105/152 (2) 72/151 (3) 64/150 (4) 49/153	At 8 h: (1) 42/152 (2) 28/151 (3) 22/150 (4) 14/153	Not calculable > 8 h	No data for single dose phase
CI: confidence interval; Dkp: dexketoprofen; h: hour; Ibu: ibuprofen; PGE: Patient Global Evaluation; PI: pain intensity; PR: pain response; SD: standard deviation; TOTPAR: total pain relief (see 'Glossary'; Appendix 1); Tram: tramadol