Comparison 5. Antidepressant/psychological therapies combination versus antidepressant alone.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Recurrence	2		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
1.1 Recurrence at 6 months	1	45	Risk Ratio (M‐H, Random, 95% CI)	0.52 [0.18, 1.49]
1.2 Recurrence at 12 months	2	98	Risk Ratio (M‐H, Random, 95% CI)	0.61 [0.36, 1.03]
1.3 Recurrence at 24 months	1	53	Risk Ratio (M‐H, Random, 95% CI)	0.56 [0.29, 1.08]
1.4 Recurrence at 36 months	1	53	Risk Ratio (M‐H, Random, 95% CI)	0.56 [0.29, 1.08]
1.5 Recurrence at final follow‐up	2	98	Risk Ratio (M‐H, Random, 95% CI)	0.56 [0.34, 0.94]
2 Death	2		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
2.1 Deaths at 6 months	1	45	Risk Ratio (M‐H, Random, 95% CI)	1.05 [0.07, 15.70]
2.2 Deaths at 12 months	2	98	Risk Ratio (M‐H, Random, 95% CI)	1.05 [0.07, 15.70]
2.3 Deaths at 24 months	1	53	Risk Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
2.4 Deaths at 36 months	1	53	Risk Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
2.5 Deaths at final outcome	2	98	Risk Ratio (M‐H, Random, 95% CI)	1.05 [0.07, 15.70]
3 Overall drop‐out rates (excluding deaths)	2		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
3.1 Drop‐outs at 6 months	1	45	Risk Ratio (M‐H, Random, 95% CI)	0.78 [0.20, 3.11]
3.2 Drop‐outs at 12 months	1	45	Risk Ratio (M‐H, Random, 95% CI)	0.78 [0.20, 3.11]
3.3 Drop‐outs at 36 months	1	53	Risk Ratio (M‐H, Random, 95% CI)	0.84 [0.21, 3.39]