Handrup 2013

Methods	Open‐label RCT; computer generated randomisation code in blocks of 20
Participants	n = 112 children aged 0‐19 years receiving a newly placed TCVC to facilitate chemotherapy (49% haematological, 51% solid tumours) 129 TCVCs inserted, including 113 TIDs and 16 TCVCs with external lines (TEs)
Interventions	Taurolidine/heparin/sodium citrate lock solution versus heparin lock solution
Outcomes	*CRBSI *Exit‐site and tunnel infections *Mechanical complications
Notes	Followed up (catheters in situ) from 12 to 1176 days Type of CVC was a risk factor for CRBSI (TIDs were less likely to get infected than TEs)
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment (selection bias)	Unclear risk	B ‐ Unclear