Date	Event	Description
1 April 2015	Amended	Contact details updated.
11 February 2015	Amended	Contact details updated.
27 March 2014	Amended	Contact details updated.
6 November 2013	New citation required but conclusions have not changed	New evidence supports conclusions of previous review
17 September 2013	New search has been performed	Two additional studies added (Di Carlo 2011; Handrup 2013)
28 June 2013	New search has been performed	New search performed
6 September 2011	Amended	PLS amended
9 November 2006	New citation required and conclusions have changed	Substantive amendment
9 November 2006	Amended	Minor update: 09/11/06 New studies sought but none found: 01/09/06 New studies found and included or excluded: 08/09/06 Conclusions changed: 19/09/06 Updating the search from July 2001 to July 2006 revealed no new RCTs in tunnelled central venous catheters. However, the improved method of testing heterogeneity I, has resulted in a change to the conclusions. Vanco prophylaxis at insertion of the catheter is not beneficial. Flushing the catheter is beneficial in high risk patients. In the excluded studies some new RCTs have been included. These were all RCTs with non‐tunnelled central venous catheters.
8 September 2006	New citation required and conclusions have changed	Original search performed.