Comparison 2. Toxicity rates.
Outcome or subgroup title | No. of studies | No. of participants | Statistical method | Effect size |
---|---|---|---|---|
1 Neutropenia G3/G4 in single‐agent cisplatin vs. combination | 4 | 1073 | Risk Ratio (IV, Random, 95% CI) | 0.04 [0.02, 0.12] |
2 Thrombocytopenia G3/4 in single‐agent cisplatin vs. combination | 4 | 1104 | Risk Ratio (IV, Random, 95% CI) | 0.16 [0.05, 0.48] |
3 Infection G3/4 in single‐agent cisplatin vs. combination | 2 | 552 | Risk Ratio (IV, Random, 95% CI) | 0.42 [0.22, 0.81] |
4 Renal dysfunction G3/G4 in single‐agent cisplatin vs. combination | 3 | 980 | Risk Ratio (IV, Random, 95% CI) | 0.81 [0.46, 1.41] |
5 Neuropathy G3/G4 in single‐agent cisplatin vs. combination | 2 | 552 | Risk Ratio (IV, Random, 95% CI) | 1.39 [0.45, 4.33] |