Comparison 2. Toxicity rates.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Neutropenia G3/G4 in single‐agent cisplatin vs. combination	4	1073	Risk Ratio (IV, Random, 95% CI)	0.04 [0.02, 0.12]
2 Thrombocytopenia G3/4 in single‐agent cisplatin vs. combination	4	1104	Risk Ratio (IV, Random, 95% CI)	0.16 [0.05, 0.48]
3 Infection G3/4 in single‐agent cisplatin vs. combination	2	552	Risk Ratio (IV, Random, 95% CI)	0.42 [0.22, 0.81]
4 Renal dysfunction G3/G4 in single‐agent cisplatin vs. combination	3	980	Risk Ratio (IV, Random, 95% CI)	0.81 [0.46, 1.41]
5 Neuropathy G3/G4 in single‐agent cisplatin vs. combination	2	552	Risk Ratio (IV, Random, 95% CI)	1.39 [0.45, 4.33]