Edmonson 1988.

Methods	Randomised Phase II trial 1980 to 1985
Participants	91 women with advanced cervical carcinoma
Interventions	Arm 1: bleomycin 20 U/m2 iv 3‐d infusion, cisplatin 60 mg/m2 d1 iv, doxorubicin 40 mg/m2 iv D1, cyclophosphamide 400 mg/m2 iv d1 q28 Arm 2: bleomycin 20 U/m2 iv 3‐d infusion, cisplatin 60 mg/m2 d1 iv q21 Bleomycin omitted after 4 cycles in both arms
Outcomes	Response rates OS
Notes	1 patient excluded as ineligible owing to second primary cancer. No ITT analysis
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Dynamic allocation system
Allocation concealment (selection bias)	Unclear risk	Not documented
Blinding (performance bias and detection bias) All outcomes	Unclear risk	Not documented but OS unlikely to be affected by blinding
Incomplete outcome data (attrition bias) All outcomes	Low risk	No missing outcome data
Selective reporting (reporting bias)	Low risk	Published report included all pre‐specified outcomes
Other bias	Low risk	No hint at any other possible biases