Malkasian 1981.

Methods	Randomised Phase II trial
Participants	41 women with recurrent and metastatic cervical cancer who had had as much surgery as was possible and radiotherapy where appropriate
Interventions	Arm 1: 5‐fluorouracil 450 mg/m2 iv d1‐5 and vincristine 1.5 mg/m2 d1 and d5 q35 Arm 2: doxorubicin 60 mg/m2 iv d1 q21
Outcomes	Response rates Toxicity OS Time to treatment failure
Notes	2 patients excluded (1 refused treatment after randomisation, 1 immediately lost to follow‐up). ITT analysis was not performed
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Not documented
Allocation concealment (selection bias)	Unclear risk	Not documented
Blinding (performance bias and detection bias) All outcomes	Unclear risk	Not documented but OS unlikely to be affected by blinding
Incomplete outcome data (attrition bias) All outcomes	Low risk	2 patients excluded. No missing outcome data
Selective reporting (reporting bias)	Low risk	Published report included all pre‐specified outcomes
Other bias	Low risk	No hint at any other possible biases