Comparison 1. Statin versus Placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Mean pressure gradient	2	1935	Mean Difference (IV, Fixed, 95% CI)	‐0.54 [‐1.88, 0.80]
2 Valve area	2	127	Mean Difference (IV, Fixed, 95% CI)	‐0.07 [‐0.28, 0.14]
3 Aortic jet velocity	1		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
4 Freedom from valve replacement	4	2360	Risk Ratio (M‐H, Fixed, 95% CI)	0.93 [0.81, 1.06]
5 Death from cardiovascular cause	3	2297	Risk Ratio (M‐H, Fixed, 95% CI)	0.80 [0.56, 1.15]
6 Hospitalisation for any reason	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
7 Severe adverse events	4		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
7.1 Muscle pain	3	2204	Risk Ratio (M‐H, Fixed, 95% CI)	0.91 [0.75, 1.09]
7.2 Hepatic enzymes elevation	2	2109	Risk Ratio (M‐H, Fixed, 95% CI)	2.66 [1.24, 5.67]
7.3 Hepatitis	2	2141	Risk Ratio (M‐H, Fixed, 95% CI)	1.14 [0.40, 3.25]
7.4 Gastrointestinal condition	3	2296	Risk Ratio (M‐H, Fixed, 95% CI)	1.10 [0.96, 1.25]
7.5 Creatine kinase	2	2109	Risk Ratio (M‐H, Fixed, 95% CI)	0.75 [0.17, 3.33]