Comparison 1. Combination therapy versus Ifosfamide.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Overall survival	2	373	Hazard Ratio (Random, 95% CI)	0.75 [0.60, 0.94]
2 Progression‐free survival	2	373	Hazard Ratio (Random, 95% CI)	0.72 [0.58, 0.90]
3 G3‐4 Nausea/vomiting	2	365	Risk Ratio (IV, Random, 95% CI)	3.53 [1.33, 9.37]
4 Diarrhoea and other GI	2	365	Risk Ratio (IV, Random, 95% CI)	1.51 [0.31, 7.52]
5 Haematological	2	365	Risk Ratio (IV, Random, 95% CI)	1.56 [0.84, 2.90]
6 Genitourinary	2	365	Risk Ratio (IV, Random, 95% CI)	1.68 [0.54, 5.18]
7 Cardiovascular	2	365	Risk Ratio (IV, Random, 95% CI)	0.63 [0.13, 3.11]
8 Hepatic	1	174	Risk Ratio (IV, Random, 95% CI)	2.05 [0.73, 5.74]
9 Neuropathy	2	365	Risk Ratio (IV, Random, 95% CI)	1.59 [0.99, 2.55]