Fig 7. Immunolocalization of GRK1 and GNB1 in cep290^fh297/fh297 mutants at 6 and 12 months of age.

Retinal cryosections of cep290^fh297/fh297 mutants and wild-type siblings were stained with polyclonal antibodies against rhodopsin kinase (A-H; GRK1) or with GNB1 polyclonal antibodies against the β subunit of rod transducin (I-P) to label rod outer segments at both 6 and 12 months of age. ROS, rod outer segments; COS, cone outer segments; ONL, outer nuclear layer; OPL, outer plexiform layer; INL, inner nuclear layer; RGC, retinal ganglion cells. Scale bar: 50 μm.