Table 1. Summary of prior studies of muscle function in dysferlin-deficient mice.
| Dysf-/- strain | Controls | Age (mths) | Sex | Muscles | In vivo measures | Ex vivo measures | Reference |
|---|---|---|---|---|---|---|---|
| A/J | A/WySnJ, C57Bl/6J | 3 | M | Dorsiflexorsb | Torque at ankle larger in dysf-/- | [23] | |
| A/J | A/WySnJ | 3–4 | M | Dorsiflexorsb | Torque at ankle no different | [24] | |
| A/J | A/WySnJ, C57Bl/6J | 2, 8 | M | Soleus EDL |
Maximum specific force lower in dysf-/- EDL (2 months) | [25] | |
| A/J | A/JOlaHsd, C57Bl/6J | 9 | F | Forelimb, Hindlimb, EDL | i. Open field behaviour lower in dysf-/- ii. Forelimb/hindlimb grip strength no different |
Maximum specific force no different | [26] |
| i. A/J ii. BLAJ iii. SJL/J iv. B10.SJL |
i. A/WySnJ ii. C57Bl/6J iii. SWR/J iv. C57BL/10J |
3–4 | M | Dorsiflexorsb | Torque at ankle lower in dysf-/- (SJL/J, B10.SJLJ) | [21] | |
| A/J, Bl.AJ | C57Bl/6J | 3–9 | NSa | N/A | Open field behaviour lower in dysf-/- (A/J, BLAJ >6 months)) | [27] | |
| BLAJ | C57Bl/6J | >20 | NSa | Forelimb, Hindlimb | i. Open field behaviour lower in dysf-/- ii. Hindlimb grip strength lower in dysf-/- |
[28] | |
| BLAJ | C57Bl/6J | 2–3, 13–15 | M/F | N/A | i. Open field behaviour lower in dysf-/- (>3 months) ii. Grip strength (hang test) lower in dysf-/- (>13 months) |
[29] | |
| SJL/J | C57BL/6J | 2–6 | M | Forelimb, Hindlimb, Soleus, EDL | i. Open field behaviour lower in dysf-/- ii. Grip strength higher in dysf-/- |
Maximum specific force lower in dysf-/- (6 months) | [30] |
| BL10.SJL-Dysfjm/AwaJ | C57Bl/10 | 3 | M | TA (in situ) | Maximum specific force no different | [31] | |
| B6.129-Dysftm1Kcam/J | C57Bl/6J | 2, 8 | NSa | EDL | Open field behaviour no different |
Maximum specific force no different | [32] |
| B6.129-Dysftm1Kcam/J | C57Bl/6J | 11 | NSa | Soleus | Gait no different | Fatigue and post fatigue recovery no different | [33] |
| Dysf-/- 129/SVemst/J | 129/SVemst/J | 14 | NSa | N/A | Voluntary wheel running lower in dysf-/- | [17] |
aNS: not specified
b Dorsiflexors muscle group; TA (tibialis anterior), extensor hallucis longus, EDL, and peroneus tertius