Comparison 3. SIMV or SIMV + PS vs HFOV.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
3.1 Death	4	996	Risk Ratio (M‐H, Fixed, 95% CI)	1.25 [0.91, 1.71]
3.2 BPD: oxygen requirement at 28 days	1	110	Risk Ratio (M‐H, Fixed, 95% CI)	3.21 [0.37, 27.83]
3.3 Moderate/ Severe BPD: Oxygen requirement at 36 weeks PCA	3	869	Risk Ratio (M‐H, Fixed, 95% CI)	1.33 [1.07, 1.65]
3.4 Death or BPD	1	356	Risk Ratio (M‐H, Fixed, 95% CI)	2.38 [1.41, 4.03]
3.5 Duration of mechanical ventilation	2	466	Mean Difference (IV, Fixed, 95% CI)	1.89 [1.04, 2.74]
3.6 Air leaks	3	1398	Risk Ratio (M‐H, Fixed, 95% CI)	0.91 [0.70, 1.19]
3.6.1 Pulmonary interstitial emphysema	1	498	Risk Ratio (M‐H, Fixed, 95% CI)	0.66 [0.44, 0.99]
3.6.2 Pneumothorax	3	900	Risk Ratio (M‐H, Fixed, 95% CI)	1.15 [0.82, 1.64]
3.7 IVH Grade 3/4	4	1010	Risk Ratio (M‐H, Fixed, 95% CI)	0.94 [0.71, 1.24]