Chan 1993.
| Study characteristics | ||
| Methods | Randomised Single centre trial Randomisation method: sealed, opaque envelopes Blinding of randomisation: yes Blinding of intervention: no Complete follow‐up: no Blinding of outcome measurement: no | |
| Participants | Gestational age < 36 weeks. Age: 1 to 21 days. RDS. In the recovery stage of the respiratory disease (at 40 bpm) Sample size: 40 PTV: 20 CMV: 20 | |
| Interventions | PTV vs CMV | |
| Outcomes | Primary: Hours of ventilation from entering the study until first extubation (weaning) Secondary: Number of infants who failed weaning Number of infants who failed extubation | |
| Notes | Ventilator types: SLE 2000 (airway pressure trigger), Sechrist IV‐100B | |
| Risk of bias | ||
| Bias | Authors' judgement | Support for judgement |
| Random sequence generation (selection bias) | Low risk | "Sealed, opaque envelopes" |
| Allocation concealment (selection bias) | Low risk | Not revealed to clinician |
| Blinding (performance bias and detection bias) All outcomes | Low risk | Quote: "protocol for weaning from ventilation was similar in both groups" Comment: clinicians not blinded to the method of weaning. |
| Blinding of participants and personnel (performance bias) All outcomes | High risk | Quote:"not possible to "blind" the clinicians" Comment: different ventilators used for the two study groups |
| Blinding of outcome assessment (detection bias) All outcomes | High risk | Comment: clinicians aware of intervention |
| Incomplete outcome data (attrition bias) All outcomes | Low risk | Comment: outcome for all participants reported |