| Study characteristics |
| Methods |
Randomised
Single centre trial
Randomisation method: sealed, opaque envelopes
Blinding of randomisation: yes
Blinding of intervention: no
Complete follow‐up: no
Blinding of outcome measurement: no |
| Participants |
GA < 35 weeks
Age < 15 days
Weaning – loaded with aminophylline
Exclusion: apnoea, failure to trigger
Sample size: 40
PTV: 20
SIMV: 20 |
| Interventions |
PTV vs SIMV |
| Outcomes |
Primary:
Duration of weaning
Secondary:
Number of infants who failed weaning
Number of infants who failed extubation |
| Notes |
Ventilator types: SLE 2000 (airway pressure trigger) |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
Low risk |
"Random selection" |
| Allocation concealment (selection bias) |
Low risk |
"Drawing a card" |
| Blinding (performance bias and detection bias)
All outcomes |
Low risk |
Done as protocol followed |
| Blinding of participants and personnel (performance bias)
All outcomes |
High risk |
Comment: clinicians likely to be aware of the intervention |
| Incomplete outcome data (attrition bias)
All outcomes |
Low risk |
Comment: outcome of all trial participants reported. |
