Erdemir 2014.

Study characteristics
Methods	Randomised Single centre trial Sealed envelope randomisation
Participants	60 prematurely born infants 30 SIMV 30 gestation < 33 weeks or birth weight < 1500 grams requiring mechanical ventilation for RDS Exclusion criteria: admission after 6 hours of age congenital cardiac, respiratory or CNS malformation congenital metabolic disease congenital pneumonia or sepsis perinatal asphyxia leak around ET tube of < 20%
Interventions	Received surfactant placed on PTV, then randomised to SIMV or PSV + VG when FiO₂ < 0.4, RR < 60, PIP 16 cmH₂O, PEEP 4 cmH₂O with adequate blood gases
Outcomes	Duration of weaning time to extubation PIP, MAP, Vt, RR at start, during and at end of weaning
Notes	58 recruited, 45 reported
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	"Sealed envelope randomisation": sequence generation unclear
Allocation concealment (selection bias)	Low risk	"Sealed envelope randomisation"
Blinding (performance bias and detection bias) All outcomes	High risk	No blinding
Blinding of participants and personnel (performance bias) All outcomes	High risk	No blinding
Blinding of outcome assessment (detection bias) All outcomes	High risk	No blinding
Incomplete outcome data (attrition bias) All outcomes	Low risk	All outcomes reported for all participants