Feature |
Thymoma |
Thymic carcinoma |
Organotypic (thymus‐like)
histological features |
Almost always present (lobular
pattern, perivascular spaces,
immature, TdT+/CD1a+/CD99+ T to cells) |
None or abortive |
CD5, CD70 and CD117 expression
in epithelial cells |
No |
Frequent (~ 60%) |
Invasion |
Variable |
Almost always |
Myasthenia gravis |
Variable: 10% to 80% |
No |
Other autoimmune diseases |
Common |
Rare |
Clinical behaviour |
Often curable by surgery;
metastases are rare
Usually long survival due to
indolent clinical course |
Often unresectable; metastases are frequent
Often short survival due to progressive
disease |