Comparison 1. Fluconazole versus amphotericin B.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Death	15	3151	Risk Ratio (M‐H, Fixed, 95% CI)	0.88 [0.73, 1.05]
1.1 I.v. or oral fluconazole vs i.v. amphotericin B	10	1586	Risk Ratio (M‐H, Fixed, 95% CI)	0.84 [0.67, 1.05]
1.2 Oral fluconazole vs oral amphotericin B	4	1063	Risk Ratio (M‐H, Fixed, 95% CI)	0.99 [0.69, 1.42]
1.3 Oral fluconazole vs oral "polyenes"	1	502	Risk Ratio (M‐H, Fixed, 95% CI)	0.83 [0.43, 1.59]
2 Death ascribed to fungal infection	10	2279	Odds Ratio (M‐H, Fixed, 95% CI)	0.95 [0.57, 1.58]
2.1 I.v. or oral fluconazole vs i.v. amphotericin B	7	1324	Odds Ratio (M‐H, Fixed, 95% CI)	1.04 [0.58, 1.87]
2.2 Oral fluconazole vs oral amphotericin B	3	955	Odds Ratio (M‐H, Fixed, 95% CI)	0.72 [0.26, 2.01]
3 Invasive infections	15	3587	Risk Ratio (M‐H, Fixed, 95% CI)	0.93 [0.72, 1.21]
3.1 I.v. or oral fluconazole vs i.v. amphotericin B	9	1486	Risk Ratio (M‐H, Fixed, 95% CI)	0.88 [0.66, 1.18]
3.2 Oral fluconazole vs oral amphotericin B	4	1063	Risk Ratio (M‐H, Fixed, 95% CI)	1.02 [0.52, 1.99]
3.3 Oral fluconazole vs oral "polyenes"	2	1038	Risk Ratio (M‐H, Fixed, 95% CI)	1.41 [0.45, 4.40]
4 Colonisation	4	1132	Risk Ratio (M‐H, Fixed, 95% CI)	0.93 [0.59, 1.47]
4.1 I.v. or oral fluconazole vs i.v. amphotericin B	2	204	Risk Ratio (M‐H, Fixed, 95% CI)	1.41 [0.76, 2.62]
4.2 Oral fluconazole vs oral amphotericin B	2	928	Risk Ratio (M‐H, Fixed, 95% CI)	0.57 [0.28, 1.18]
5 Use of rescue drug	9	2616	Risk Ratio (M‐H, Random, 95% CI)	1.06 [0.80, 1.41]
5.1 I.v. or oral fluconazole vs i.v. amphotericin B	6	1201	Risk Ratio (M‐H, Random, 95% CI)	1.34 [0.76, 2.37]
5.2 Oral fluconazole vs oral amphotericin B	2	879	Risk Ratio (M‐H, Random, 95% CI)	0.81 [0.62, 1.06]
5.3 Oral fluconazole vs oral "polyenes"	1	536	Risk Ratio (M‐H, Random, 95% CI)	1.04 [0.76, 1.43]
6 Dropouts	8	1122	Risk Ratio (M‐H, Random, 95% CI)	0.76 [0.44, 1.29]
6.1 I.v. or oral fluconazole vs i.v. amphotericin B	4	631	Risk Ratio (M‐H, Random, 95% CI)	0.95 [0.69, 1.30]
6.2 Oral fluconazole vs oral amphotericin B	3	243	Risk Ratio (M‐H, Random, 95% CI)	0.30 [0.12, 0.74]
6.3 Oral fluconazole vs oral "polyenes"	1	248	Risk Ratio (M‐H, Random, 95% CI)	2.71 [1.01, 7.30]
7 Dropouts because of adverse effects	14	3489	Risk Ratio (M‐H, Random, 95% CI)	0.33 [0.14, 0.78]
7.1 I.v. or oral fluconazole vs i.v. amphotericin B	8	1388	Risk Ratio (M‐H, Random, 95% CI)	0.23 [0.10, 0.55]
7.2 Oral fluconazole vs oral amphotericin B	4	1063	Risk Ratio (M‐H, Random, 95% CI)	0.14 [0.03, 0.60]
7.3 Oral fluconazole vs oral "polyenes"	2	1038	Risk Ratio (M‐H, Random, 95% CI)	1.76 [0.51, 6.04]