Comparison 1. Infusion duration less than 6 hours versus infusion duration 6 hours or more.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1.1 Clinical heart failure	5	557	Risk Ratio (M‐H, Random, 95% CI)	0.27 [0.09, 0.81]
1.2 (Sub)clinical heart failure combined	4		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
1.2.1 (Sub)clinical heart failure combined (subclinical defined as >=10% decrease in LVEF)	1	82	Risk Ratio (M‐H, Random, 95% CI)	0.76 [0.46, 1.26]
1.2.2 (Sub)clinical heart failure combined (subclinical defined as >=15% decrease in LVEF)	1	52	Risk Ratio (M‐H, Random, 95% CI)	0.31 [0.03, 2.78]
1.2.3 (Sub)clinical heart failure combined (subclinical defined as a fall in LVEF of > 20%)	1	62	Risk Ratio (M‐H, Random, 95% CI)	0.04 [0.00, 0.60]
1.2.4 (Sub)clinical heart failure combined (subclinical defined as a decrease in LVEF)	1	240	Risk Ratio (M‐H, Random, 95% CI)	0.36 [0.15, 0.90]
1.3 Response rate	3		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
1.3.1 Response rate (defined as complete or partial remission)	2	292	Risk Ratio (M‐H, Random, 95% CI)	1.20 [0.65, 2.22]
1.3.2 Response rate (defined as good response)	1	178	Risk Ratio (M‐H, Random, 95% CI)	1.23 [0.91, 1.66]
1.4 Overall survival	2	322	Hazard Ratio (IV, Random, 95% CI)	1.42 [0.61, 3.30]