Date	Event	Description
20 January 2016	New citation required but conclusions have not changed	Summary of most important changes in the update: The search for eligible studies was updated to December 2015. We identified long‐term follow‐up data of one of the earlier included RCTs on different infusion durations in children with acute lymphoblastic leukaemia: with a longer follow‐up none of the assessed outcomes changed. However, more data on the risk of bias became available, changing the risk of performance bias from unclear to high. For the 'Risk of bias' assessment we used the most recent recommendations of the Cochrane Childhood Cancer, which are based on the Cochrane Handbook for Systematic Reviews of Interventions. All publications (including those already included in earlier versions of the review) were scored using the new 'Risk of bias' criteria.
9 December 2015	New search has been performed	The search for eligible studies was updated to December 2015.
11 May 2009	New citation required and conclusions have changed	Summary of most important changes in the update: The search for eligible studies was updated to November 2008 using an updated search strategy. Five new RCTs were included: one addressing anthracycline infusion duration and four assessing anthracycline peak doses. We also identified a study awaiting classification (addressing anthracycline peak doses); characteristics of this trial are provided. As opposed to the original review, in which no trials addressing anthracycline peak doses were identified, now there was evidence available for different combinations of anthracycline peak doses. For different anthracycline infusion durations the conclusions did not change. We did identify an error in the original analysis of response rate of different anthracycline infusion durations. The effect estimate changed from a risk ratio of 0.83 (95% CI 0.45 to 1.54; P = 0.6) to a risk ratio of 1.20 (95% CI 0.65 to 2.22; P = 0.6). However, the overall conclusion did not change.
14 October 2008	Amended	Converted to new review format.
27 June 2006	New citation required and conclusions have changed	Substantive amendment